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Kumar Harder posted an update 6 months, 1 week ago
An excellent correlation in the final Cobb angle calculation was achieved between the smallest distance point (SDP) method and two experts (> 0.95), with a small error in the angle estimation compared (MAE less then 3°). The proposed method could provide a potential tool for the automatic estimation of the Cobb angle to improve the efficiency and accuracy of the treatment workflow for AIS.
Stereotactic needle biopsy remains the cornerstone for tissue diagnosis for tumors located in regions of the brain that are difficult to access through open surgery.
We perform a meta-analysis of the literature to examine the relation between number of samples taken during biopsy and diagnostic yield, morbidity and mortality.
We identified 2416 patients from 28 cohorts in studies published in PubMed database that studied stereotactic needle biopsies for tumor indications. Meta-analysis by proportions and meta-regression analyses were performed.
On meta-analysis, the morbidity profile of the published needle biopsy studies clustered into three groups studies that performed < 3 samples (n = 8), 3-6 samples (n = 13), and > 6 samples during biopsy (n = 7). Pooled estimates for biopsy related morbidity were 4.3%, 16.3%, and 17% for studies reporting < 3, 3-6, and > 6 biopsy samples, respectively. While these morbidity estimates significantly differed (p < 0.001), the diagnostic yields reported for studies performing < 3 biopsies, 3-6 samples, and > 6 samples were comparable. Pooled estimates of diagnostic yield for these three groups were 90.4%, 93.8%, and 88.1%, respectively. Mortality did not significantly differ between studies reporting differing number of samples taken during biopsy.
Our meta-analysis suggests that morbidity risk in needle biopsy is non-linearly associated with the number of samples taken. There was no association between the number of biopsies taken, and diagnostic yield or mortality.
Our meta-analysis suggests that morbidity risk in needle biopsy is non-linearly associated with the number of samples taken. There was no association between the number of biopsies taken, and diagnostic yield or mortality.
Glioma remains incurable and a life limiting disease with an urgent need for effective therapies. Sonodynamic therapy (SDT) involves systemic delivery of non-toxic chemical agents (sonosensitizers) that accumulate in tumor cells or environment and are subsequently activated by exposure to low-frequency ultrasound to become cytotoxic agents. Selleckchem SD-36 Herein, we discuss proposed mechanisms of action of SDT and provide recommendation for future research and clinical applications of SDT for gliomas.
Review of literature of SDT in glioma cell cultures and animal models published in Pubmed/MEDLINE before January, 2021.
Different porphyrin and xanthene derivatives have proven to be effective sonosensitizers. Generation of reactive oxygen species and free radicals from water pyrolysis or sonosensitizers, or physical destabilization of cell membrane, have been identified as mechanisms of SDT leading to cell death. Numerous studies across glioma cell lines using various sonosensitizers and ultrasound parameters have documrrently underway.This article is intended to recognize and the life time contribution that Dr. Viswanathan Natarajan has made to the advancement of lipid metabolism and lipid signaling. In particular, his major contributions in the last three decades have been made in understanding how lipids such as phosphatidic acid, lysophosphatidic acid, sphingosine 1-phosphate and cardiolipin contribute to healthy lung functions and to a variety of lung pathologies. We celebrate a truly remarkable career and look forward to seeing even more remarkable discoveries.In the current Anthropocene Era, with numerous escalating challenges for biodiversity conservation, the inclusion of the social dimension into management decisions regarding wildlife and protected areas is critical to their success. By conducting 354 questionnaires in a Mediterranean protected area (the Biosphere Reserve of Bardenas Reales, Northern Spain), we aim to determine sociodemographic factors influencing knowledge levels and perceptions of species and functional groups as, emblematic and threatened. We found that hunters and animal husbandry workers knew more species than other social actors. Additionally, the perception of functional groups as threatened or emblematic differed between social actor groups, with statistically significant associations between perceptions and the characteristics of respondents. Interestingly, we found that although elusive steppe species are globally considered as endangered, these species were the least known by all social actor groups and rarely perceived as emblematic. This research is a novel approach and provides a better understanding of how perceptions can facilitate conservation decisions, particularly regarding endangered species.Salivary gland neoplasms are uncommon, and most exhibit epithelial differentiation. Mesenchymal neoplasms of the salivary gland are rare, and the incidence ranges from 1.9% to 5%. The aim of this study is to identify the types and clinical-pathological features of mesenchymal salivary neoplasm and review their differential diagnosis. A retrospective search for mesenchymal neoplasms of salivary glands from our institution’s pathology archives from the 2004-2021 period and consultation files of one of the authors (AER) was performed. The clinical data were obtained from available medical records, and the histological slides and ancillary studies were retrieved and reviewed. We identified a total of 68 cases that form the study cohort. Thirty-five patients were male, and thirty-three patients were female, with a mean age of 48 years (range, 7 months-79 years), and the male to female ratio was 1.94. Sixty-three (92.6%) of sixty-eight tumors were benign and included 38 (56%) lipomas, 9 (13%) hemangiomas, 7 (10.3%)rable outcome and were disease-free after treatment. Mesenchymal neoplasms of salivary gland are rare; most are benign and demonstrate adipocytic, endothelial, and schwannian differentiation; awareness of their development is important for adequate diagnosis. The mainstay of treatment is surgical excision, with the extent determined by tumor type. Adjuvant therapy is reserved for high-grade sarcomas and may be given in a neoadjuvant or adjuvant setting.
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