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Burke Bennetsen posted an update 6 months, 3 weeks ago
of positive and negative susceptibility sources within the same volume element as well as its limitations is presented and validated quantitatively in both simulation and phantom experiments for the first time. An application to multiple sclerosis lesions shows promising results for in vivo usability.We conducted a retrospective review of fMRI studies of complex syntax, in order to study the stability of the neural bases of mechanisms engaged in syntactic processing. Our review set out rigorous selection criteria of studies which we discuss, including transparency and minimality of the contrasts between stimuli, and the presence of whole brain analyses corrected for multiple comparisons. Seventeen studies with 316 participants survived our sieve. We mapped the 65 resulting maxima onto JuBrain, a state-of-the-art cytoarchitectonic brain atlas (Amunts et al., 2020), and a sharp picture emerged syntactic displacement operations (a k a MOVE) produce highly consistent results, activating left Broca’s region across-the-board and unambiguously; to a somewhat lesser extent, maxima clustered in left posterior brain regions, including the STS/STG. The few studies of syntactic tree-building operations (a k a MERGE) produce a murkier picture regarding the involvement of the left IFG. We conclude that the extant data decisively point to the JuBrain-defined Broca’s region as the main locus of complex receptive syntax in healthy people; the STS/STG also are involved, but to a lesser extent.
To examine the cumulative incidence of and covariates’ association with new onset anxiety and depression in implantable cardioverter defibrillator (ICD) patients during 24months of follow-up in patients without depression and anxiety at implant.
Patients (n=1040; 155 (14.9%) women; mean age 64.2±10.6) with a first-time ICD enrolled in the national, multi-center prospective observational DEFIB-WOMEN study comprised the study cohort. We obtained information on demographic and clinical data from the Danish Pacemaker and ICD Register.
During 24months of follow-up, 138 (14.5%) patients developed new onset anxiety and 109 (11.3%) new onset depression. Age≥60 and an anxiety score between 3 and 4 and 5-7 on the Hospital Anxiety and Depression Scale (HADS) were associated with different hazards of new onset anxiety during follow-up. Age≥60 and a HADS depression score between 3 and 4 and 5-7 were associated with different hazards of new onset depression.
During 24months of follow-up, respectively 14.5% and 11.3% of patients developed new onset anxiety and depression, suggesting that screening patients at several timepoints, and in particular those with even minimally elevated HADS scores at baseline, may be warranted to identify patients at risk for poor health outcomes.
During 24 months of follow-up, respectively 14.5% and 11.3% of patients developed new onset anxiety and depression, suggesting that screening patients at several timepoints, and in particular those with even minimally elevated HADS scores at baseline, may be warranted to identify patients at risk for poor health outcomes.Hydrogels based on short peptide molecules are interesting biomaterials with wide present and prospective use in biotechnologies. A well-known possible drawback of these materials can be their limited mechanical performance. In order to overcome this problem, we prepared Fmoc-Phe3self-assembling peptides by a biocatalytic approach, and we reinforced the hydrogel with graphene oxide nanosheets. The formulation here proposed confers to the hydrogel additional physicochemical properties without hampering peptide self-assembly. We investigated in depth the effect of nanocarbon morphology on hydrogel properties (i.e. Ipatasertib mouse morphology, viscoelastic properties, stiffness, resistance to an applied stress). In view of further developments towards possible clinical applications, we have preliminarily tested the biocompatibility of the composites. Our results showed that the innovative hydrogel composite formulation based on FmocPhe3 and GO is a biomaterial with improved mechanical properties that appears suitable for the development of biotechnological applications.Recently, increased attention has been focused on antibacterial photodynamic therapy (APDT) to treat multidrug-resistant bacterial infection due to the antibiotic abuse. Methylene blue has been used as a kind of efficient and cheap commercial photosensitizer in APDT. However, due to high hydrophilicity, methylene blue is not able to be transcellular intaken and accumulated efficiently. To promote accumulation and APDT efficiency of methylene blue, lipopeptide surfactin-methylene blue complex has been prepared through electrostatic interaction. The complex under LED irradiation was found to effectively reduce 5.0 Log10 CFU and 7.6 Log10 CFU for P. aeruginosa and S. aureus, respectively. The bacterial reduction efficiency is slightly higher than free methylene blue. The photosensitizers accumulation and APDT targeting protein have been characterized by fluorescence spectroscopy, fluorescence microscopy and protein electrophoresis techniques. These results demonstrated that more surfactin-methylene blue complex could be accumulated more into the cell, and inactivate bacteria through destroying intracellular protein under LED illumination. In comparison, free methylene blue under light could inactivate bacteria through destroying membrane protein and lipid structures. These results would provide valuable insight for developing advanced clinical medicine and designing photo-drug for photodynamic therapy.This study investigated cross-linguistic interference in German low-proficient late learners of Spanish. We examined the modulating influence of gender congruency and cognate status using a syntactic violation paradigm. Behavioural results demonstrated that participants were more sensitive to similarities at the syntactic level (gender congruency) than to phonological and orthographic overlap (cognate status). Electrophysiological data showed that they were sensitive to syntactic violations (P600 effect) already in early acquisition stages. However, P600 effect sizes were not modulated by gender congruency or cognate status. Therefore, our late learners of Spanish did not seem to be susceptible to influences from inherent noun properties when processing non-native noun phrases at the neural level. Our results contribute to the discussion about the neural correlates of grammatical gender processing and sensitivity to syntactic violations in early acquisition stages.
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