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Prater Ibrahim posted an update 6 months, 3 weeks ago
e a better utility in estimating obesity-induced hepatosteatosis in children. This is the first study to show the association between TMI and hepatosteatosis in children.Introduction Fibromyalgia syndrome (FS) comprises general body pain, sleep disturbances, and fatigue. Vitamin B12 (VB), Vitamin D (VD), and iron deficiencies lead to similar complaints. First, this study aimed to evaluate the VB, VD, and ferritin levels of patients with FS. Second, it aimed to investigate whether there was a relationship between these parameters and FS severity.Material and Methods The study included 58 female patients with FS and 58 healthy females as a control group. The patients completed the Fibromyalgia Impact Questionnaire (FIQ), Visual Analog Scale (VAS), fatigue questionnaire, Pittsburgh sleep quality scale, and the Short Form-36 (SF-36). iCRT3 ic50 This study examined the VD, VB, and ferritin levels of the patient and control groups.Results The VB (240.0 vs 291.0 pg/ml, p less then 0.001), VD (12.5 vs 20.0 ng/ml, p=0.013), and ferritin levels (21.2 vs 32.0 , ng/ml, p=0.009) of the FS patients were determined to be significantly lower than those of the control group. A negative correlation was determined between the number of tender points and VB, VD, and ferritin levels. In the regression analysis, we found low ferritin levels (odds ratio 1.036, 95% confidence interval 1.015-1.058, p less then 0.001) and VB (OR 1.010, CI 1.002-1.018, p=0.010) to be an independent risk factor for FS.Conclusions There may be a relationship between VB, VD, and ferritin levels and the number of tender points in patients with FS. Levels of iron and VB may play a vital role in FS etiopathogenesis. However, VD levels may not risk factor for FS etiopathogenesis.Mindfulness has been widely studied in Western psychology for reducing psychological distress. However, several scholars noted that in the East, where the concept originated, mindfulness may be understood differently. In Eastern cultures such as Thailand, mindfulness is not only employed to deal with suffering but also to promote well-being. To the best of our knowledge, no studies have been undertaken to evaluate the relationship between traditional mindfulness and eudaimonic well-being in Eastern contexts. In the present study, we investigated the relationships between mindfulness and eudaimonic well-being in Thai contexts. We also explored the mediating roles of rumination and emotion dysregulation on this relationship. Data were collected from 312 Thai undergraduates who completed a measure of Eudaimonic Well-Being, the Freiburg Mindfulness Inventory, the Rumination-Reflection Questionnaire, and the Difficulties in Emotion Regulation Scale. Results largely supported our hypotheses. Mindfulness was found to have a positive and direct association with eudaimonic well-being. Rumination and emotion dysregulation partially mediated this association. Additionally, both rumination and emotion dysregulation had negative and direct association with eudaimonic well-being. The findings highlight the positive influences of mindfulness on well-being. The benefits of mindfulness for improvement of eudaimonic well-being through reducing rumination and emotion dysfunction are discussed.Obesity has been identified mainly as a raise in the body’s adiposity leading to prolonged overshoot of caloric intake over expenditure. Obesity has significant health-altering implications which have been shown to be implicated in the pathogenesis and progression of other diseases through its extensive physiological assaults. The prevalence of overweight and obesity has been an increasing epidemic worldwide. The number of obese births was even on the increase, with an increasing number of women of reproductive age registering as obese. Obesity is related to adverse perinatal outcomes and increased morbidity and mortality in pregnant women. The potential risk for multiple antenatal, postpartum, intrapartum, and neonatal complications is maternal obesity. Greater risk of developing Gestational Diabetes Mellitus (GDM), pregnancy induced hypertension (PIH), pre-eclampsia, risk of venous embolism, increased need for labor induction, and cesarean sections in the mother have been recorded in a comprehensive analysis of pregnancy complications associated with obesity. The link between obesity, gestational diabetes, and pregnancy outcomes will be briefly shown in this article.
The study assessed the prevalence and associated factors of behavioural risk factors of non-communicable diseases (NCDs) among adolescents in four Caribbean countries.
In all 9,143 adolescents (15 years=median age) participated in the cross-sectional “2016 Dominican Republic, 2016 Suriname, 2017 Jamaica, and 2017 Trinidad and Tobago Global School-Based Student Health Survey (GSHS)”. Eight behavioural risk factors of NCDs were assessed by a self-administered questionnaire.
Prevalence of each behavioural NCD risk factor was physical inactivity (84.2%), inadequate fruit and vegetable intake (82.2%), leisure-time sedentary behaviour (49.6%), daily≥2 soft drinks intake (46.8%), ever drunk (28.6%), twice or more days a week fast food consumption (27.6%), having overweight/obesity (27.4%), and current tobacco use (13.8%). Students had on average 3.6 (SD=1.4), and 79.0% had 3-8 behavioural NCD risk factors. In multivariable linear regression, psychological distress and older age increased the odds, and attending school and parental support decreased the odds of multiple behavioural NCD risk factors.
A high prevalence and co-occurrence of behavioural risk factors of NCDs was discovered and several factors independently contributing to multiple behavioural NCD risk factors were identified.
A high prevalence and co-occurrence of behavioural risk factors of NCDs was discovered and several factors independently contributing to multiple behavioural NCD risk factors were identified.
The Next Generation Sequencing (NGS) based mutational study of hereditary cancer genes is crucial to design tailored prevention strategies in subjects with different hereditary cancer risk. The ease of amplicon-based NGS library construction protocols contrasts with the greater uniformity of enrichment provided by capture-based protocols and so with greater chances for detecting larger genomic rearrangements and copy-number variations. Capture-based protocols, however, are characterized by a higher level of complexity of sample handling, extremely susceptible to human bias. Robotics platforms may definitely help dealing with these limits, reducing hands-on time, limiting random errors and guaranteeing process standardization.
We implemented the automation of the CE-IVD SOPHiA Hereditary Cancer Solution™ (HCS) libraries preparation workflow by SOPHiA GENETICS on the Hamilton’s STARlet platform. We present the comparison of results between this automated approach, used for more than 1,000 DNA patients’ samples, and the performances of the manual protocol evaluated by SOPHiA GENETICS onto 240 samples summarized in their HCS evaluation study.