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McGuire Klit posted an update 6 months, 4 weeks ago
In addition, both proposed methods could segment all the swing phases using only the acceleration data, bringing advantage in terms of power consumption. This implies that swing-segmentation methods using machine learning could be applied to various motion-analysis environments by dividing motion phases with less restriction on IMU placement.Animal shelters can be stressful environments and time in care may affect individual dogs in negative ways, so it is important to try to reduce stress and arousal levels to improve welfare and chance of adoption. A key element of the stress response is the activation of the autonomic nervous system (ANS), and a non-invasive tool to measure this activity is heart rate variability (HRV). Physiologically, stress and arousal result in the production of corticosteroids, increased heart rate and decreased HRV. Environmental enrichment can help to reduce arousal related behaviours in dogs and this study focused on sensory environmental enrichment using olfactory and auditory stimuli with shelter dogs. The aim was to determine if these stimuli have a physiological effect on dogs and if this could be detected through HRV. Sixty dogs were allocated to one of three stimuli groups lavender, dog appeasing pheromone and music or a control group, and usable heart rate variability data were obtained from 34 dogs. Stimuli were applied for 3 h a day on five consecutive days, with HRV recorded for 4 h (treatment period + 1 h post-treatment) on the 5th and last day of exposure to the stimuli by a Polar® heart rate monitor attached to the dog’s chest. HRV results suggest that music activates both branches of the ANS, which may be useful to relieve both the stress and boredom in shelter environments.Fosfomycin is being increasingly prescribed for multidrug-resistant bacterial infections. In patients with systemic involvement, intravenous fosfomycin is usually administered as a partner drug, as part of an antibiotic regimen. Hence, the knowledge of fosfomycin pharmacodynamic interactions (synergistic, additive, indifferent and antagonistic effect) is fundamental for a proper clinical management of severe bacterial infections. We performed a systematic review to point out fosfomycin’s synergistic properties, when administered with other antibiotics, in order to help clinicians to maximize drug efficacy optimizing its use in clinical practice. Interactions were more frequently additive or indifferent (65.4%). Synergism accounted for 33.7% of total interactions, while antagonism occurred sporadically (0.9%). Clinically significant synergistic interactions were mostly distributed in combination with penicillins (51%), carbapenems (43%), chloramphenicol (39%) and cephalosporins (33%) in Enterobactaerales; with linezolid (74%), tetracyclines (72%) and daptomycin (56%) in Staphylococcus aureus; with chloramphenicol (53%), aminoglycosides (43%) and cephalosporins (36%) against Pseudomonas aeruginosa; with daptomycin (97%) in Enterococcus spp. and with sulbactam (75%) and penicillins (60%) and in Acinetobacter spp. fosfomycin-based antibiotic associations benefit from increase in the bactericidal effect and prevention of antimicrobial resistances. Taken together, the presence of synergistic interactions and the nearly total absence of antagonisms, make fosfomycin a good partner drug in clinical practice.The aim of this study was to investigate the annual incidence of Escherichia coli isolates in urinary tract infections (UTIs) and the antimicrobial resistance of the third-generation cephalosporin (3GCs) to E. coli, including the factors associated with the resistance in hospitalized children in Taiwan. A large electronic database of medical records combining hospital admission and microbiological data during 2004-2018 was used to study childhood UTIs in Taiwan. Annual incidence rate ratios (IRR) of E. coli in children with UTIs and its resistant rate to the 3GCs and other antibiotics were estimated by linear Poisson regression. Factors associated with E. coli resistance to 3GCs were assessed through multivariable logistic regression analysis. E. coli UTIs occurred in 10,756 unique individuals among 41,879 hospitalized children, with 92.58% being community associated based on urine culture results reported within four days after the hospitalization. The overall IRR E. coli UTI was 1.01 (95% confidence interval (CI) 0.99-1.02) in community-associated (CA) and 0.96 (0.90-1.02) in healthcare-associated infections. The trend in 3GCs against E. coli increased (IRR 1.18, 95% CI 1.13-1.24) over time in CA-UTIs. Complex chronic disease (adjusted odds ratio (aOR), 2.04; 95% CI, 1.47-2.83) and antibiotics therapy ≤ 3 months prior (aOR, 1.49; 95% CI, 1.15-1.94) were associated with increased risk of 3GCs resistance to E. Brepocitinib manufacturer coli. The study results suggested little or no change in the trend of E. coli UTIs in Taiwanese youths over the past 15 years. Nevertheless, the increase in 3GCs-resistant E. coli was substantial. Interventions for children with complex chronic comorbidities and prior antibiotic treatment could be effective in reducing the incidence of 3GCs-resistant E. coli in CA-UTIs in this region and more generally.Diabetic retinopathy (DR) is a major microvascular complication that can lead to severe visual impairment in patients with diabetes. The elevated oxidative stress and increased reactive oxygen species (ROS) production induced by hyperglycemia have been reported to play an important role in the complex pathogenesis of DR. Astaxanthin (AST), a natural carotenoid derivative, has been recently recognized as a strong free radical scavenger and might, therefore, be beneficial in different diseases, including DR. In this study, we evaluated the potential role of AST as an antioxidative and antiapoptotic agent in protecting retinal cells and also investigated the involvement of the PI3K/Akt/Nrf2 pathway in AST-mediated effects. We treated high glucose-cultured mouse photoreceptor cells (661W) with different concentrations of AST and analyzed ROS production and cell apoptosis in the different regimens. Moreover, we also analyzed the expression of PI3K, Akt, Nrf2, and Phase II enzymes after AST treatment. Our results showed that AST dose-dependently reduced ROS production and attenuated 661W cell apoptosis in a high glucose environment.