Noel Han

The development, fast-tracking, and approval of SARS-CoV-2 nanotechnology-based vaccines has transformed the seemingly daunting challenges for clinically translating nanomedicines into measurable hurdles that can be overcome. Due to the tremendous scientific achievements that have occurred in response to the COVID-19 pandemic, years, perhaps even…[Read more]

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a central role in cholesterol homeostasis in humans as a major regulator of LDLR levels. PCSK9 is an intriguing protease in that it does not act by proteolysis but by preventing LDLR recirculation from endosomes to the plasma membrane. This, and the inexistence of any other proteolytic…[Read more]

Online supplemental material is available for this article.Background Cerebrospinal fluid-venous fistulas (CVFs) are one of the less common etiologic causes of spontaneous intracranial hypotension. DMH1 inhibitor CVFs are most commonly treated with open surgical ligation and have reportedly not responded well to percutaneous treatments. Purpose To…[Read more]

Online supplemental material is available for this article.Background Cerebrospinal fluid-venous fistulas (CVFs) are one of the less common etiologic causes of spontaneous intracranial hypotension. DMH1 inhibitor CVFs are most commonly treated with open surgical ligation and have reportedly not responded well to percutaneous treatments. Purpose To…[Read more]

We demonstrate a versatile technique to generate a broadband optical frequency comb source in the C-band. This is accomplished by nonlinear spectral broadening of a phase modulated comb source driven by dual frequency offset locked carriers. The locking is achieved by setting up a heterodyne optical frequency locked loop to lock two phase…[Read more]

Stroke is one of the leading causes of disability and death. Increasing evidence indicates that β-hydroxybutyrate (BHB) exerts beneficial effects in treating stroke, but the underlying mechanism remains largely unknown. In this study, we injected different doses of BHB into the lateral ventricle in middle cerebral artery occlusion (MCAO) model…[Read more]

This review is an overview of these novel technologies with a focus on their pathophysiological background, procedural details, available evidence, and with a critical perspective about their potential future implementation in the clinical care of STEMI patients.

Despite the widespread use of systemic antibiotics to prevent infections in…[Read more]