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Vargas Carrillo posted an update 6 months ago
The net effect of nitrogen enrichment on productivity could have been 14.5% more on average over 20 years in monocultures if not for nitrogen-induced decreases in pH and about 28.5% more on average over 20 years in 16 species communities if not for nitrogen-induced species richness losses. Together, these results suggest that the positive effects of nutrient enrichment on biomass production can diminish in their magnitude over time, especially because of soil acidification in low diversity communities and especially because of plant diversity loss in initially high diversity communities.
An increasing number of patients survive rectal cancer, resulting in more patients living with the side-effects of the treatment. Exploring quality of life before and after treatment enables follow-up and additional treatment to be adjusted to the patient’s needs. The aim of the study was to describe the quality of life during the 24months following diagnosis and to identify risk factors for poor quality of life.
This is a prospective cohort study of patients with rectal cancer followed up by extensive questionnaires. Patients from 16 surgical departments in Denmark and Sweden from 2012 to 2015 were included. The self-assessed quality of life was measured with a seven-point Likert scale.
A total of 1110 patients treated with curative intent were included, and the response rate at the 24-month follow-up was 71%. Patients with rectal cancer assessed their quality of life before start of treatment as poorer than that of a reference population. At the 12- and 24-month follow-up, the quality of life on group level had recovered to the same level as for the reference population. Risk factors for poor quality of life included bother with urinary, bowel and stoma function. A reference population was used for comparison.
The quality of life of patients with resectable rectal cancer recovered to levels comparable to a reference population 12 and 24months after diagnosis. Our results indicate that the urinary, bowel and stoma function has an impact on quality of life.
The quality of life of patients with resectable rectal cancer recovered to levels comparable to a reference population 12 and 24 months after diagnosis. Our results indicate that the urinary, bowel and stoma function has an impact on quality of life.Amyloid fibrils found in plaques in Alzheimer’s disease (AD) brains are composed of amyloid-β peptides. Oligomeric amyloid-β 1-42 (Aβ42) is thought to play a critical role in neurodegeneration in AD. Here, we determine how size and conformation affect neurotoxicity and internalisation of Aβ42 assemblies using biophysical methods, immunoblotting, toxicity assays and live-cell imaging. We report significant cytotoxicity of Aβ42 oligomers and their internalisation into neurons. In contrast, Aβ42 fibrils show reduced internalisation and no toxicity. Sonicating Aβ42 fibrils generates species similar in size to oligomers but remains nontoxic. The results suggest that Aβ42 oligomers have unique properties that underlie their neurotoxic potential. Furthermore, we show that incubating cells with Aβ42 oligomers for 24 h is sufficient to trigger irreversible neurotoxicity.
The aim of this study was to examine the microbial composition of early (after 3days, D3) and mature biofilms (after 31days, D31) on materials typically used in implant/abutment buildups. Implant/abutment materials with different surface roughness values (R
) were compared to detect differences in the quantity and quality of bacterial composition.
Four different materials were investigated rough implant surface (sand-blasted acid-etched titanium, Ti-p), implant collar (machined titanium, Ti-m), titanium abutment (Ti6Al4V), and zirconium dioxide abutment (ZrO
). Fourteen periodontally healthy subjects received mandibular acrylic devices with four disks (one for each material) facing the anterior lingual area. The total bacterial count was analyzed using RT-qPCR. Both presence and proliferation of 20 selected bacterial species were assessed with microarrays.
The highest mean total cell counts (x10
±standard deviation) were detected at D3 on ZrO
(5.63±4.83; R
=0.74µm), followed by Ti-p (4.53±5.00ow surface roughness showed less biofilm accumulation.
The aim of the study was to assess insurants’ views on various forms of medical rehabilitation of the German Federal Pension Insurance (DRV).
In ten focus groups, participants (n=78, 65% female, M=52.2 years) discussed the advantages and disadvantages of inpatient rehabilitation, outpatient rehabilitation, rehabilitation parallel to work, and case management. Central to discussion were treatment modalities such as setting, duration and cooperation with other actors in the health care system. The focus groups were transcribed and analyzed qualitatively (Mayring, 2008).
Many participants expressed the need to be removed from their daily routine in order to concentrate on rehabilitative treatment. The perceived lower treatment intensity and double pressure of outpatient rehabilitation are feared to have a negative effect on treatment outcome. According to participants, the fit between the rehabilitation form and the needs of the rehabilitant is crucial.
The qualitative data can be used to adjust rehabilitation treatment to insurants’ needs.
The qualitative data can be used to adjust rehabilitation treatment to insurants’ needs.
Work-related interventions and alliances between healthcare institutions and companies that aim to support employees with common mental disorders (CMD) returning to work are still quite rare in Germany. The present study examines a small sample of existing alliances and interventions with the aim to describe their cooperation forms and treatment approaches, to identify their strengths and weaknesses, and thus to provide guidance for their further development and dissemination.
Five alliances/interventions were selected on the basis of a web search. MGCD0103 chemical structure Subsequently 11 group discussions and 17 qualitative interviews with involved health care professionals and occupational stakeholders (n=44) as well as employees with CMD (n=17) were conducted and evaluated by documentary method and qualitative content analysis.
The examined interventions follow either a person oriented self-management or a systemic case management approach. The self-management approach focusses on what has to be done by the person him-/herself to get back to work (focus on individual adaption).