Corcoran Gibbons

Both ALA and cis-9, trans-11 CLA reduced the CCND2 expression and cis-9, trans-11 CLA induced apoptosis. ALA and cis-9, trans-11 CLA significantly down-regulated the expression of STAR, CYP19A1, FSHR, LHCGR and decreased the 17β-Estradiol (E2) and progesterone (P4) production. In conclusion, dietary lipids did not improve in vitro embryo…[Read more]

The purpose of this study was to determine the efficacy of nanoparticle-encapsulated Fidgetin-like 2 (FL2) siRNA (FL2-NPsi), a novel therapeutic agent targeting the

gene, for the treatment of corneal alkaline chemical injury.

Eighty 12-week-old, male Sprague-Dawley rats were divided evenly into 8 treatment groups prednisolone, empty…[Read more]

Moreover, the pretreatment with a tropomyosin-receptor-kinase B (TrkB) antagonist ANA-12 (0.5 mg/kg) significantly blocked the beneficial effects of (R)-ketamine in DSS-induced UC model. The study shows that (R)-ketamine can produce beneficial effects in DSS-induced colitis model through TrkB stimulation. Therefore, (R)-ketamine may be a novel…[Read more]

We studied the levels microRNA (miR-21, miR-221, miR-222, and miR-429) in blood serum, thoracic duct lymph, and breast cancer tissue, as well as the cell composition of the axillary lymph node in Wistar female rats with chemically induced breast cancer. The levels of miR-221 and miR-429 in the tumor tissue and in the lymph correlated with the…[Read more]

The volumetric Dice similarity coefficient between the actual and simulated gross tumor volumes (GTVs) of the patients calculated across respiration phases was found to range between 0.80 ± 0.03 and 0.92 ± 0.01. The average error in estimating tumor’s center of mass calculated across respiration phases ranged between 0.50 ± 0.10 (mm) and 1.04 ±…[Read more]

Kinetic characterization of this mutant shows a significant increase in the PL affinity. Through molecular dynamics simulation and MM/PBSA calculations some residues, important for substrate interactions and catalysis, were identified in the wild type and in the mutated ancestor. Interestingly, a strong epistatic interaction responsible for the…[Read more]

are needed.

Evidence shows that maternal near miss is negatively associated with various aspects of quality of life. see more This highlights the importance of addressing the adverse effects associated with maternal near miss and follow up maternal near miss after discharge. Quality of life is a multidimensional concept that is assessed in…[Read more]