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Morton Khan posted an update 6 months ago
During the period from March 2022 to December 2022, the research school’s initiation period was dedicated to setting up the infrastructure and formulating the necessary action plans. PhD projects, which will begin in January 2023, are anticipated to be finished within a period of five years. Doctoral coursework, networking engagements, and the dissemination of research results are additional facets of the research program.
Through a network of industry, public sector, and academic partners, the research school defines research problems related to the development, evaluation, implementation, and dissemination of digital technology-assisted methods and processes pertinent to societal needs. Ultimately, this will fuel innovation to boost health outcomes, enhance the quality of care, and strategically prioritize resource allocation.
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Weight loss strategies for populations with overweight and obesity increasingly incorporate the use of digital tools. Evidence affirms the viability of digital tools for community-based obesity management, whereas specialist weight management programs are currently in the nascent stage of evidence development. A comprehensive evaluation of the utilization of digital tools by patients anticipating their first appointment at a specialist weight management clinic has not yet been conducted.
The research aimed to determine participants’ interest, acceptance, and engagement in utilizing a digital platform for specialist weight management support.
The registration of this observational study was as a service innovation. The NHS-certified digital tool was made available to every patient awaiting a first appointment within the University Hospitals Coventry and Warwickshire NHS Trust’s tier 3 weight management service. Interest and engagement data for the digital resource were obtained. gpcr signals inhibitors To portray patient demographics, routine clinical data were utilized. Patient feedback regarding the use of digital technologies in a specialized weight management service was garnered through the conduct of focus groups.
The 199 patients listed for treatment were informed about the existence of the digital tool. A substantial percentage (n=102, 513%) of patients indicated interest in the app; over a third (n=68, 34%) of patients actually interacted with the app A substantial portion, one-third, of patients awaiting treatment (n=63, 32%), failed to acknowledge the invitation. Furthermore, 34 (17%) of those on the waiting list expressed a lack of interest in the application. Individuals exhibiting emotional eating and a higher body mass index showed an increased interest in the Gro Health app. Application engagement was inversely proportional to the presence of male users. Across all demographics, including age, ethnicity, metabolic markers (glycemia and lipid profile), there was no discernible variation in interest toward the Gro Health application.
The provision of digital resources, including Gro Health, is practical for patients anticipating their first weight management consultation with a specialist. Investigations in the future should explore the obstructions and drivers of interaction with digital resources. Importantly, the effectiveness of such tools should be further evaluated in specialist weight management settings.
Digital tools, like Gro Health, are a viable option for patients anticipating their initial consultation with specialist weight management services. Future studies should investigate the constraints and driving forces behind engagement with digital tools. Moreover, further research into the effectiveness of such tools within specialized weight management services is imperative.
Next-generation lithium-ion batteries often utilize silicon-based anode materials, however, these materials suffer from drawbacks such as low initial Coulombic efficiency and inadequate interfacial stability. A lithium-containing 5 nm Li2O-lithicone hybrid laminated film was fabricated on a silicon electrode by using atomic layer deposition (ALD) and molecular layer deposition (MLD) in this work. By providing an extra lithium surface around silicon cores, the laminated film can help to partially offset the lithium loss that occurs during battery cycling. A laminated Li2O-lithicone interface’s characterization displays gradual elemental modifications, leading to a hybrid solid electrolyte interphase involving Li2CO3, Li2O, LixPOFy, and LiF. Analysis of the laminated structure via finite element modeling and morphological characterization reveals a reduction in interfacial stress, thus preserving the integrity and reactivity of the silicon composite anode throughout cycling. Subsequently, the laminated lithium film is associated with enhanced Li+ migration kinetics at the electrode interface, as validated by galvanostatic intermittent titration testing and density functional theory calculations. The silicon anode, benefiting from the inherent advantages discussed earlier, achieved a remarkable initial Coulombic efficiency of 912%, a rate performance of 1460 mA h g⁻¹ at 2 A g⁻¹, and a reversible capacity surpassing 646 mA h g⁻¹ after 850 charge-discharge cycles. The work on lithium-based hybrid films, precisely engineered via ALD/MLD techniques, underscores the improvements in advanced silicon anode battery performance and deepens the understanding of the mechanisms governing interfacial stability and reaction kinetics.
Crack lithography is undeniably important for the construction of microstructured materials. The unconventional use of cracking, in opposition to the traditional view of cracks as defects, has great potential in high-resolution and high-throughput production. Nonetheless, the capability for controlling nanoscale crack patterns is presently insufficient. This report introduces a nanoscale, programmable angle-dependent method for controlling crack formation, leveraging standard electron-beam lithography techniques. The electron-beam lithography process enabled the creation of multiscale poly(methyl methacrylate) patterns exhibiting a broad spectrum of shapes, sizes, and large areas, substantially expanding its processing capacity. Simultaneously, we observed the connection between neighboring architectural components and fractures, producing either a halt in fracture propagation or the development of additional fractures. We further illustrated that angle-dependent nanoscale fractures can be employed in physical unclonable functions, promising significant applications in information security. We hold the belief that our programmable nanoscale crack patterning strategy opens up fresh possibilities and diverse perspectives for the field of nanofabrication.
Early detection of hepatocellular cancer, a disease often linked with high mortality, is crucial for improved patient survival. The population of patients with cirrhosis, especially those whose condition is linked to non-alcoholic fatty liver disease or viral hepatitis, is at a considerably higher risk of hepatocellular carcinoma (HCC), and forms the principal target group for screening. The 6-monthly HCC screening protocol, comprising serum alpha-fetoprotein and ultrasound liver examinations, has demonstrated suboptimal sensitivity. Consequently, a renewed focus on alternative and more accurate HCC screening markers is warranted.
Our study, TENDENCY, is focused on validating the utility of novel HCC screening markers—methylated septin 9, urinary volatile organic compounds, and urinary peptides—and on studying their role in various manifestations of liver disease.
This multicenter nested case-control study investigates methylated septin 9 plasma levels in patients with confirmed HCC, contrasting them with patients with cirrhosis. In addition to other procedures, comparing urine samples aids in the identification of HCC-specific volatile organic compounds and peptides. A pilot study at University Hospital Coventry & Warwickshire yielded findings that led us to project a sample size of 308 participants (n=88, 29% of whom presented with hepatocellular carcinoma; n=220, 71% with cirrhosis). Each participant will provide urine and plasma samples, which will be stored frozen at -80°C until the end of recruitment. Urinary volatile organic compounds will be detected by gas chromatography-mass spectrometry, and capillary electrophoresis-mass spectrometry will ascertain the identity of urinary peptides. The real-time polymerase chain reaction method will be applied to qualitatively determine the presence of methylated septin 9 in plasma. The study will be subject to continuous monitoring by the Research and Development team at University Hospital Coventry & Warwickshire.
March 2023 marked the culmination of the recruitment process. The TENDENCY study’s analysis is currently being conducted, and it is estimated that this will be finalized by November 2023.
The high mortality associated with hepatocellular cancer is not countered by the effectiveness of existing screening tests. Improved outcomes for hepatocellular cancer (HCC) will result from the use of more sensitive plasma and urinary biomarkers for screening in clinical practice, allowing for earlier detection.
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The mortality rate is significantly higher for cancer patients who pursue alternative treatment strategies compared to those who undergo conventional cancer therapies. Stories from cancer patients hint at the appearance of paid ads for alternative cancer treatments on social media, but the amount and type of this marketing remain undisclosed. This context highlights the pressing need for a thorough examination of social media advertising related to cancer treatments that are not conventional.
Employing a systematic approach, this study investigated the advertising techniques of prominent alternative cancer treatment practitioners on various Meta platforms, including Facebook, Instagram, Messenger, and the Audience Network. Our research focused on determining (1) the presence of paid advertisements for alternative cancer treatment on Meta’s social media, (2) the strategies and messaging used by alternative treatment providers to target potential patients, and (3) how the purported efficacy of these treatments is communicated.
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