Salisbury Bengtsen

© 2020 S. Karger AG, Basel.BACKGROUND At present, there is no clear understanding of the effect of long-duration spaceflight on the major enzymes that govern the metabolism of omega-6 and omega-3 fatty acids. To address this gap in knowledge, we used data from the NASA Twins Study, which includes a multiscale omics investigation of the changes…[Read more]

In chronic pancreatitis, PSCs are activated by proinflammatory cytokines to induce pancreatic fibrogenesis. HDAC inhibition protected against the pancreatic fibrosis and the apoptosis of PSCs through induced apoptosis and depressed inflammation. In our study, we found that miR-15 and miR-16 decreased significantly in chronic pancreatitis and HDAC…[Read more]

Both methods were comparable for diversity and evenness indices with similar ranks for species. Multivariate analysis showed that the MacKinnon Lists Technique and MaxN detected similar differences in community composition at different depths and protection status. However, the MacKinnon Lists Technique detected significant differences between…[Read more]

KEY RESULTS The model was able to describe drug-induced changes in dPdtmax , HR and MAP for all drugs included in the developed framework adequately by incorporating appropriate drug effects on either dPdtmax , HR and/or TPR. Consistent with the Starling’s law, incorporation of LVEDP as a covariate on dPdtmax to correct for the pre-load effect was…[Read more]