Hess Dillard

Immunotherapy is a vital component in cancer treatment. However, due to the complex genetic bases of cancer, a clear prediction index for efficacy has not been established. Tumor mutation burden (TMB) is one of the essential factors that affect immunotherapeutic efficacies, but it has not been determined whether the mutation is associated with the…[Read more]

Irregular splicing was associated with tumor formation and progression in renal cell carcinoma (RCC) and many other cancers. By using splicing data in the TCGA SpliceSeq database, RCC subtype classification was performed and splicing features and their correlations with clinical course, genetic variants, splicing factors, pathways activation and…[Read more]

Improvements in cancer survival mean that an increasing number of survivors may live long enough beyond their initial cancer to be diagnosed with additional independent primary cancers. PMAactivator The proportion of newly diagnosed cancers that are second- or higher-order primaries and how this proportion has changed over the past several decades…[Read more]

Ice-sheet responses to climate warming and associated sea-level rise depend sensitively on the form of the slip law that relates drag at the beds of glaciers to their slip velocity and basal water pressure. Process-based models of glacier slip over idealized, hard (rigid) beds with water-filled cavities yield slip laws in which drag decreases with…[Read more]

OFS-1 is thus a promising new imaging tool for detecting abnormal bone resorption.Large amounts of food are wasted during the food supply chain. This loss is in part due to consumer confusion over dates on food packages that can indicate a variety of quality indicators in the product (e.g., expiration date, “best by” date, “sell by” dates, etc.).…[Read more]