• Ipsen McDonough posted an update 6 months ago

    Early discontinuation of adjuvant endocrine therapy (ET) is problematic among breast cancer survivors, with previous studies suggesting that up to 50% of women do not adhere to the recommended full 5 years of ET treatment.

    To identify the association between early discontinuation of ET in the Trial Assigning Individualized Options for Treatment (TAILORx) and modifiable risk factors, polypharmacy, and types of additional medications such as antidepressants and opioids.

    This post hoc analysis includes a subgroup of 954 patients with breast cancer in TAILORx, a randomized clinical trial conducted from April 7, 2006, to October 6, 2010. All participants received a diagnosis of hormone receptor-positive, ERBB2-negative, axillary node-negative breast cancer and started ET within a year of study entry. Analyses were conducted in the intent-to-treat population. Statistical analysis took place from January 15, 2020, to April 6, 2021.

    Participants completed measures on cancer-related health-related quality of l NCT00310180.

    ClinicalTrials.gov Identifier NCT00310180.The aim of this study was to assess the impact of oral conditions on the oral health-related quality of life (OHRQoL) of early adolescents aged 11 to 14 years in the rural population of a Brazilian municipality. Adolescents attending public schools in the municipality participated in the study. OHRQoL was measured using the short Brazilian version of the Child Perceptions Questionnaire (CPQ11-14) with four domains oral symptoms, functional limitations, emotional wellbeing and social wellbeing. A higher score indicates a more negative perception of the adolescent regarding his/her OHRQoL. Oral conditions such as dental caries, malocclusion and dental trauma were evaluated using DMTF index, Dental Aesthetics Index (DAI) and Andreasen criteria, respectively. The variables sex and age, number of siblings, parents’ schooling, family monthly income, number of times of tooth-brushing/day and visits to the dentist/year were also evaluated. Descriptive analysis and regression models were performed. Of the 202 participants, 94 (46.5%) were female and 108 (53.5%) were male. Adolescents from low-income families (p=0.042) and with more severe malocclusion (p=0.037) scored higher in the CPQ11-14. Those with severe malocclusion scored higher in the emotional wellbeing domain (p=0.009). Females scored higher than males in the oral symptoms domain (p=0.002). Adolescents from low-income families scored higher in the social wellbeing domain (p=0.006). Malocclusion negatively affected the OHRQoL of adolescents from a Brazilian rural area, mainly regarding emotional wellbeing. Negative repercussions were also observed among females and adolescents whose families had lower income.The aim of this article is to describe the cross-cultural adaptation of a quality of life (QoL) questionnaire for individuals with potentially malignant oral diseases (OPMD) in the Brazilian context. This methodological study consisted of the following stages of content validation process (1) Conceptual and item equivalence stage during which a comprehensive literature review on the construct was performed; (2) Semantic equivalence. The extensive literature review showed that the questionnaire enables evaluation of QoL, and that domains and items are also considered and relevant to the Brazilian context. Finerenone Semantic equivalence was evaluated as satisfactory by a committee of judges. The scope of the domains was analyzed according to the agreement rate and presented results equal to or greater than 84%. The general Content Validity Calculation (CVC) was 0.84 for clarity and 0.92 for representativeness. Of the 20 items, 18 presented CVC values above 0.8. The indicators for content validation, pre-test and operational equivalence indicate that the Brazilian version of the OPMD QoL questionnaire is a promising instrument and a tool that seems valid to evaluate the quality of life of people with oral potentially malignant disorders. As a next step, it is important to measure equivalences to evaluate the psychometric properties of this instrument.This study evaluated the impact of COVID-19 on the endodontic treatment routine. It was a cross-sectional study using an online questionnaire applied to endodontists to collect information about practical modifications during endodontic treatment to protect professionals and patients against the COVID-19 outbreak. A total 1105 participants from Brazil participated in the survey. More than 90% of respondents identify the high risk of COVID-19 infection to dentists and the need to change some clinical practices. Most respondents (60.1%) are partially following social isolation. The need for a change in Personal Protective Equipment (PPE) during dental appointments was mentioned by 97.1% of respondents. The use of minimal adequate PPE during the pandemic period was associated with the area of residence and marital status of participants. Only 30% of respondents say they use the minimal adequate PPE. Most respondents will change cavity access preparation to reduce virus dissemination. Other changes in endodontic appointments were described in the survey greater attention to biosafety measures, duration of dental appointments, and duration of intervals between appointments. Endodontists still need to identify the best arrangement for performing their procedures safely during the COVID-19 pandemic. Specific guidelines require detailed information for each specialty and its procedures.The aim of this in vitro study was to evaluate the influence of treatment time on the remineralization performance of nanoencapsulated fluoride dentifrices on initial carious lesions. Ninety-six human enamel samples were allocated to eight groups (n = 12) 50% NanoF + 50% free NaF, 100% NanoF, 100% NaF (positive control), and placebo (negative control), using two different treatment times (one and five minutes) for each dentifrice tested. After the carious lesion induction, the specimens were submitted to a pH remineralizing cycling model for seven days. Surface microhardness was measured before and after carious lesion induction and after treatment. The percentage of surface remineralization was calculated for each study time. Data were analyzed using two-way ANOVA and ANOVA repeated-measures tests followed by the Bonferroni correction (p less then 0.05). Remineralization differences were observed in the dentifrices analyzed according to the treatment time used. NanoF formulations with 50% (one-min treatment) and 100% (five-min treatment) promoted significant remineralization of enamel after the caries challenge when compared to the placebo dentifrice (p less then 0.

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