Loft Brewer

Mammalian pluripotent stem cells are thought to exist in two states naïve and primed states. selleck Generally, unlike those in rodents, pluripotent stem cells in primates including humans are regarded as being in the primed pluripotent state. Recently, several groups reported the existence of naïve pluripotent stem cells in humans. In this s…[Read more]

Low-dose adjuvant epigenetic therapy (AET) reduced metastasis and promoted survival in mouse models. ©2020 American Association for Cancer Research.Mismatch repair (MMR)-deficient tumors exhibit proteome-wide protein instability and aggregation. ©2020 American Association for Cancer Research.The MaMTH-DS assay detected inhibitors of mutant EGFR i…[Read more]

Importantly, the photo-mediated NO release could be manipulated in living cells and showed promising applications in the treatment of corneal wounds. In addition to delivering NO, the current design enabled the synergistic delivery of NO and other therapeutic payloads by taking advantage of NO release-mediated traceless crosslinking of the…[Read more]

43±1.55 vs. 8.22±2.22, P=0.0104; vitamin D 23.08±11.0 vs. 32.07±19.2, P=0.0007) than that in the nsMPP group; both sMPP and nsMPP did not show a deficiency of vitamins E and D. Logistic regression analysis revealed that vitamin A deficiency was significantly (OR 0.001, 95% CI 0.001-0.334, P=0.009) associated with sMPP, and vitamin A sup…[Read more]

We find that unless Pakistan and Afghanistan manage to increase the quality of bivalent OPV (bOPV) pSIAs, which we model as intensity (i.e., sufficiently high-coverage bOPV pSIAs that reach missed children), the model does not lead to successful eradication of WPV1. Achieving WPV1 eradication, the global objectives of the GPEI, and a successful…[Read more]