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Kelley Johannesen posted an update 6 months, 3 weeks ago
The TaHATs in expression also responded to temperature changes, and were all significantly upregulated after being infected by barley streak mosaic virus (BSMV), Chinese wheat mosaic virus (CWMV) and wheat yellow mosaic virus (WYMV).
These results suggest that TaHATs may have specific roles in the response to viral infection and provide a basis for further study of TaHAT functions in T. CDK2IN4 aestivum plant immunity.
These results suggest that TaHATs may have specific roles in the response to viral infection and provide a basis for further study of TaHAT functions in T. aestivum plant immunity.
The major pathogenesis associated with Fasciola hepatica infection results from the extensive tissue damage caused by the tunnelling and feeding activity of immature flukes during their migration, growth and development in the liver. This is compounded by the pathology caused by host innate and adaptive immune responses that struggle to simultaneously counter infection and repair tissue damage.
Complementary transcriptomic and proteomic approaches defined the F. hepatica factors associated with their migration in the liver, and the resulting immune-pathogenesis. Immature liver-stage flukes express ~ 8000 transcripts that are enriched for transcription and translation processes reflective of intensive protein production and signal transduction pathways. Key pathways that regulate neoblast/pluripotent cells, including the PI3K-Akt signalling pathway, are particularly dominant and emphasise the importance of neoblast-like cells for the parasite’s rapid development. The liver-stage parasites display differenthat can be exploited to understand parasite development more fully and for the design of novel control strategies to prevent host liver tissue destruction and pathology.Targeted Radionuclide Therapies (TRTs) based on Auger emitting radionuclides have the potential to deliver extremely selective therapeutic payloads on the cellular level. However, to fully exploit this potential, suitable radionuclides need to be applied in combination with appropriate delivery systems. In this review, we summarize the state-of-the-art production, purification, chelation and applications of two promising candidates for Targeted Auger Therapy, namely antimony- 119 (119Sb) and mercury-197 (197Hg). Both radionuclides have great potential to become efficient tools for TRT. We also highlight our current progress on the production of both radionuclides at TRIUMF and the University of Wisconsin.
The pseudo-cereal quinoa has attracted worldwide attention in recent years, due to it being considered a functional food. This stress-tolerant crop has historically been used by Andean cultures as a staple food. Nowadays, the consumption of quinoa in high-income countries is increasing due to it being associated with numerous health benefits, namely related to cardiovascular health.
We have carried out an extensive review on quinoa, including its main uses, applications, and components (nutrients, antinutrients, and bioactives) and their relationship with biological activities and cardiovascular health. Key findings and Conclusions Quinoa possesses numerous activities, including protection against cardiovascular, metabolic, and degenerative diseases, improvement of the immune system, reduction of symptoms associated with post-menopause, and promotion of muscle mass increase. Some of the quinoa’s activities are due to its balanced amino acid profile, high fiber content, presence of phosphorus, iron, potassiated with post-menopause, and promotion of muscle mass increase. Some of the quinoa’s activities are due to its balanced amino acid profile, high fiber content, presence of phosphorus, iron, potassium, magnesium, vitamin E, and B vitamins. A plethora of bioactives can also be found in quinoa, such as phytosterols, saponins, phenolics, bioactive peptides, and phytoecdysteroids. More research is needed to better understand the mechanisms of action involved in the biological/therapeutic action of some quinoa components, namely those related to the potential to reduce cardiovascular disease (CVD) risk markers. The knowledge of factors that affect quinoa variability, such as processing conditions, is also of great importance for being able to obtain more benefits from this crop.Salvia miltiorrhiza, a traditional Chinese medicine, also named Danshen in China, is widely used for the treatment of cardiovascular disease. It demonstrates multiple biological functions, such as anti-oxidative stress, anti-inflammation and anti-thrombosis. Diabetic angiopathy is one of the diabetic complications with macro- and microangiopathy. Macroangiopathy mainly occurs in arteries, while the microangiopathy mainly includes diabetic retinopathy and nephropathy. Many factors associated with diabetes, such as metabolic abnormalities and oxidative stress, can induce vascular lesions. These factors promote the accumulation of lipids as well as inflammatory cytokines, increase the production of extracellular cell-matrix, and impair endothelium functions, thereby leading to vascular dysfunction. This review attempts to summarize the progress of the studies of Salvia miltiorrhiza on diabetic angiopathy, including improving endothelial function, anti- oxidative stress, reducing the risk of vascular blockage, inhibiting inflammation as well as regulating lipid metabolism. We also summarize the pharmacological activity of bioactive components in Salvia miltiorrhiza and the delivery systems. We made the conclusion that Salvia miltiorrhiza can be used as a potential auxiliary drug for the treatment of diabetic angiopathy.
Oriental planetree (Platanus orientalis L.) leaf was recorded as a remedy against inflammatory problems and to stop the pain, i.e. toothache or knee pain in “The Canon of Medicines” by Avicenna and was also being documented in the Iranian Traditional Medicine. Although such a utilization has not been described in reliable sources, recently use of its leaves as herbal tea has become popular among laypeople. Previous studies have shown that only the nonpolar extract from the leaves may have such efficacy, while possible benefits when it is used as herbal tea have not been investigated.
The present study aims to reveal the possible efficacy and safety profile of aqueous extract from P. orientalis leaf.
Aqueous extract of the leaves was submitted to in vivo and in vitro tests to determine its anti-inflammatory, antinociceptive, antimutagenic activities and also reveal its safety profile.
The aqueous extract (400 mg/kg) procured weak and non-significant anti-inflammatory and antinociceptive activities. Meanwhile, the aqueous extract demonstrated antimutagenic activity in very high concentrations.
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