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Prater Myers posted an update 6 months, 3 weeks ago
The ideal maxillofacial prosthesis should have fine and thin boundaries that bind with the surrounding facial structures and possess high tear strength. This study aims to determine the best percentages of nanofiller (TiO
) and intrinsic pigment (silicone functional intrinsic) that could be mixed in as additives to improve the tear strength of Cosmesil M511 and VST50F silicone elastomers with the least effect on their hardness.
In this
experimental study, a total of 80 samples, 40 for each elastomer, were fabricated. SCH58261 research buy Each elastomer sample was split into two equal groups to test for tear strength and Shore A hardness. Each group consisted of 20 samples, including 10 control samples without additives and 10 experimental samples with additives (mixtures of 0.2 wt% nano-TiO
+ 0.25 wt% intrinsic pigment and 0.25 wt% nano-TiO
+ 0.25 wt% intrinsic pigment for the Cosmesil M511 and VST50F silicone elastomers, respectively). Two-way ANOVA and Tukey test were used for comparison;
< 0.05 was considered statistically significant.
Significant differences in tear strength were found among all tested groups (
< 0.05). The tear strength of the experimental subgroups significantly increased compared with the control subgroups (
< 0.05). Significant differences in Shore A hardness were also observed among all tested groups (
< 0.05) except between the experimental subgroups of both materials, where a nonsignificant difference was obtained (
> 0.05).
Incorporation of select percentages of TiO
nanofiller and intrinsic pigment into Cosmesil M511 and VST50F silicone elastomers yields improvements in tear strength with a slight increase in hardness.
Incorporation of select percentages of TiO2 nanofiller and intrinsic pigment into Cosmesil M511 and VST50F silicone elastomers yields improvements in tear strength with a slight increase in hardness.
Post and core treatment is commonly performed for endodontically treated teeth to replace the lost tooth structure and reinforce and protect the remaining dental tissue. This study aimed to compare the effect of three-core building materials on fracture resistance of endodontically-treated teeth restored with fiber-reinforced composite (FRC) posts and ParaPosts.
This
, experimental study evaluated 108 sound, single-rooted mandibular first premolars extracted for orthodontic purposes. The teeth were randomly divided into nine groups (
= 12) of control (no endodontic or restorative treatment), FRC + Photo Core (Group 2), FRC + LuxaCore (Group 3), FRC + Core Max II with bonding agent (Group 4), FRC + Core Max II without bonding agent (Group 5), ParaPost + Photo Core (Group 6), ParaPost + LuxaCore (Group 7), ParaPost + Core Max II with bonding agent (Group 8), and ParaPost + Core Max II without bonding agent (Group 9). The fracture resistance was measured by applying the load at 45° angle relative to the
Fracture resistance is independent of the type of core building material used, and the tested products had no superiority over each other. The mean fracture resistance of FRC post groups were significantly higher than that of ParaPost groups. Furthermore, Core Max II + bonding agent yielded insignificantly higher fracture resistance than Core Max II without bonding agent.
Scaling and root planing (SRP) for the treatment of periodontitis may be less effective in some patients. This study evaluated the effectiveness of local doxycycline as an adjunct to SRP among smokers with periodontitis compared to SRP alone in randomized controlled trials (RCTs).
For this systematic review and meta-analysis, PubMed and Scopus databases were searched till November 2018 for English publications. RCTs that compared the effect of local doxycycline adjunct to SRP among smokers with periodontitis were selected. Patient characteristics, disease characteristics, and outcome data on clinical attachment level (CAL) and periodontal probing depth at 1, 3- and 6-month follow-up was extracted. Quality of selected studies was assessed by the revised Cochrane Risk of Bias 2.0 tool. Random effects model and trial sequential analysis were performed. GRADE approach was used to assess the quality of evidence.
> 0.05 was considered as statistically significant.
Five trials were included in the review. Local use of doxycycline as an adjunct to SRP was effective in gain of 1.1 mm (0.47-1.74,
= 0.091) in CAL at 6 months calculated from two studies. The evidence was of low quality, and at least a total of 866 patients are required for conclusiveness.
Local doxycycline as an adjunct to SRP significantly improved clinical attachment in smokers with periodontitis and can be recommended. Studies are required with long-term follow-up and patient-related outcome data.
Local doxycycline as an adjunct to SRP significantly improved clinical attachment in smokers with periodontitis and can be recommended. Studies are required with long-term follow-up and patient-related outcome data.COVID-19, which is caused by SARS-CoV-2, has been declared a global pandemic. Although effective strategies have been applied to treat the disease, much is still unknown about this novel virus. SARS-CoV-2 enters host cells through ACE2, which is a component of the angiotensin-regulating system. Binding of the SARS-CoV-2 S protein to ACE2 is a prerequisite for SARS-CoV-2 infection. Many studies have indicated a close relationship between ACE2 expression and SARS-CoV-2 infection. The structural basis of receptor recognition by SARS-CoV-2 has been analyzed in detail. The diversification of the ACE2 sequence due to ACE2 polymorphisms and alternative splicing has to a large extent affected the susceptibility of different species. Differential ACE2 expression makes specific populations more prone to be infected, and ACE2 also plays a role in the broad tropism of SARS-CoV-2 in human organs and tissues. In this review, we comprehensively summarize how the ACE2 expression profile affects the host range and tropism of SARS-CoV-2, which will provide mechanistic insights into the susceptibilities and outcomes of SARS-CoV-2 infection.