• Lundgaard Carstensen posted an update 6 months ago

    n the asthma trial were lower than in atopic dermatitis trials and were similar for dupilumab- and placebo-treated patients. Most events were mild to moderate, most recovered/resolved, and none prompted study withdrawal. These results are similar to those reported in adult trials and support a drug-disease interaction. CLINICALTRIALS.

    NCT03054428, NCT02612454, NCT02414854. Conjunctivitis in Dupilumab Clinical Trials for Adolescents with Atopic Dermatitis or Asthma (MP4 18453 kb).

    NCT03054428, NCT02612454, NCT02414854. Conjunctivitis in Dupilumab Clinical Trials for Adolescents with Atopic Dermatitis or Asthma (MP4 18453 kb).

    This retrospective, single-center study was performed to systemically describe the characteristics and outcomes of patients with severe and critical coronavirus disease 2019 (COVID-19) in Wuhan, analyze the risk factors, and propose suggestions for clinical diagnosis and treatment to guide the subsequent clinical practice.

    A total of 753 consecutive patients with COVID-19 admitted to the West Campus of Wuhan Union Hospital from January22, 2020 to May7, 2020 were enrolled in this study. Demographic, clinical, laboratory, and outcome data were extracted from the electronic medical records of Wuhan Union Hospital and were exhaustively analyzed using R (version 3.6.1).

    A total of 493 severe and 228 critical cases out of 753 COVID-19 cases were considered in this study. Among the critical cases, the death rate was 79.4%, and age was a risk factor for death. Compared to the severe disease group, the critical disease group had higher white blood cell (WBC) and neutrophil counts and a decreased lymphocyte countedictor of early death in critical cases, and anticoagulation therapy was correlated with an improved prognosis of patients with critical COVID-19.

    Our results showed large differences between patients with severe and critical COVID-19. During the course of COVID-19 in the critical disease group, the incidence of hypoproteinemia, anemia, thrombocytopenia, and coagulation disorders increased significantly, which highlighted the importance of medical care in the first week after admission. LDH could act as an independent predictor of early death in critical cases, and anticoagulation therapy was correlated with an improved prognosis of patients with critical COVID-19.An increasing number of studies examined the potential effects of ambient particulate matter (PM PM2.5 and PM10-PMs with diameters not greater than 2.5 and 10 μm, respectively) pollution on the risk of depression and suicide; however, the results have been inconclusive. This study aimed to determine the overall relationship between PM exposure and depression/suicide based on current evidence. We conducted a systematic review and meta-analysis of current available studies. Thirty articles (20 for depression and 10 for suicide) with data from 1,447,313 participants were included in the meta-analysis. For a 10 μg/m3 increase in short-term exposure to PM2.5, we found a 2% (p  less then  0.001) increased the risk of depression and a 2% (p = 0.001) increased risk of suicide. A 10 μg/m3 increase in long-term exposure to PM2.5 was associated with a more apparent increase of 18% (p = 0.005) in depression risk. In addition, a 10 μg/m3 increase in short-term exposure to PM10 was associated with a 2% (p = 0.003) increase in depression risk and a 1% (p = 0.002) increase in suicide risk. Subgroup analyses showed that associations between PM and depression were more apparent in people over 65 years and from developed regions. Besides, the study design and study quality might also have an impact on their associations. The meta-analysis found that an increase in ambient PM concentration was strongly associated with an increased risk of depression and suicide, and the associations for depression appeared stronger for smaller particles (PM2.5) and at a long-term time pattern.One of humanity’s most significant problems in the twenty-first century revolves around how to balance the mitigation of environmental pollution while achieving sustainable economic development. Despite increased awareness and dedication to climate change, the planet is still seeing a drastic decrease in the volume of pollutant emissions. This study explores the long-run and causal impact of economic growth, financial development, urbanization, and gross capital formation on Malaysia’s CO2 emissions based on the STIRPAT framework. The current paper employs recently developed econometric techniques such as Maki co-integration, auto-regressive distribution lag (ARDL), fully modified OLS (FMOLS), dynamic ordinary least square (DOLS), and wavelet coherence and gradual shift causality tests to investigate these interconnections. The advantage of the gradual shift causality test is that it can capture the causality in the presence of a structural break(s). The findings from the Maki co-integration and ARDL bounds tests reveal evidence of cointegration among the variables. The ARDL test reveals that economic growth, gross capital formation, and urbanization exert a positive impact on CO2 emissions. Furthermore, the wavelet coherence test reveals that there is a significant dependency between CO2 emissions and economic growth, gross capital formation, and urbanization. The Toda Yamamoto and Gradual shift causality tests reveal that there is a (a) unidirectional causality from urbanization to CO2 emissions, (b) unidirectional causality from economic growth to CO2 emissions, and (c) unidirectional causality from gross capital formation to CO2 emissions.The paper aims to investigate the influencing factors that drive the temporal and spatial differences of CO2 emissions for the transportation sector in China. selleckchem For this purpose, this study adopts a Logistic Mean Division Index (LMDI) model to explore the driving forces of the changes for the transport sector’s CO2 emissions from a temporal perspective during 2000-2017 and identifies the key factors of differences in the transport sector’s CO2 emissions of China’s 15 cities in four key years (i.e., 2000, 2005, 2010, and 2017) using a multi-regional spatial decomposition model (M-R). Based on the empirical results, it was found that the main forces for affecting CO2 emissions of the transport sector are not the same as those from temporal and spatial perspectives. Temporal decomposition results show that the income effect is the dominant factor inducing the increase of CO2 emissions in the transport sector, while the transportation intensity effect is the main factor for curbing the CO2 emissions. Spatial decomposition results demonstrate that income effect, energy intensity effect, transportation intensity effect, and transportation structure effect are important factors which result in enlarging the differences in city-level CO2 emissions.

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