Herskind Harrell

Precision psychiatry is attracting increasing attention lately as a recognized priority. One of the goals of precision psychiatry is to develop tools capable of aiding a clinically informed psychiatric diagnosis objectively. Cognitive, inflammatory and immunological factors are altered in both bipolar disorder (BD) and schizophrenia (SZ), however,…[Read more]

A patient with coronary artery fistula should be considered as high risk for intraoperative hemodynamic decompensation. In this article, we report the case of a 70-year-old man affected by a complex congenital coronary artery fistula defect. The patient underwent general anesthesia for spine surgery with permissive hypotension. The development of…[Read more]

4±11.8, 42.8±21.8 and 66.6±39.1. Emergence of resistance as indicated by >2 log growth on MICx8 recovery media was maximal at AUC/MIC ratios of 10-40 and was suppressed at AUC/MIC ratios of ≥250. CONCLUSIONS The dominant PDI for fosfomycin against S.aureus are Cmax/MIC in terms of reduction of bacterial load and AUC/MIC in terms of supp…[Read more]

Furthermore, the potential for supercritical fluid technology to overcome the shortcomings associated with conventional drug formulation methods is reviewed.BACKGROUND Oxaliplatin, used as first-choice treatment for colorectal cancer (CRC), induces sinusoidal endothelial injury and portal hypertension. This study investigated the characteristics…[Read more]

SP data can be adopted in situations where we would like to have consumer choice data, but we currently do not. These are often hypothetical situations to analyze the decision-making process of individuals. With SP data it is possible to analyze trade-offs patients make when choosing between treatment options where these hard to measure attributes…[Read more]

In recent years, sulforaphane (SFN) has been shown to have antitumor effects. To better understand the molecular basis of SFN intervention in estrogen-dependent breast cancer, integrated multi-omics data analysis was used to provide evidence and insights into molecular biology. MCF-7 breast cancer cells were treated with estradiol (E2) or/and SFN.…[Read more]