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Mohammad Frandsen posted an update 6 months ago
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Cocaine is considered a cardiovascular risk factor, yet it is not included in the frequently used risk stratification scores. Moreover, many guidelines provide limited advice on how to diagnose and treat cocaine-associated chest pain (CACP). This study aimed to determine the current practice for CACP patients in emergency departments and coronary care units throughout the Netherlands.
An anonymous online questionnaire-based survey was conducted among Dutch emergency physicians and cardiologists between July 2015 and February 2016. The questionnaire was based on the American Heart Association CACP treatment algorithm.
A total of 214 subjects were enrolled and completed the questionnaire. Go 6983 All responders considered cocaine use a risk factor for developing acute coronary syndrome (ACS), nevertheless 74.4 % of emergency physicians and 81.1 % of cardiologists do not always question chest pain patients about drug use. Of all responders, 73.6 % never perform toxicology screening. Most responders (60 %) observe the AHA scientific statement of 2008, many respondents utilize ß-blockers for CACP patients, which is supported by published evidence since the statement appeared..Nile tilapia (Oreochromis niloticus) samples were collected at monthly intervals between July 2018 and June 2019 from 3 sampling sites (El-Rahawy, Sabal and Tala) situated along the Rosetta branch of the Nile, Egypt, to monitor the presence of 100 pesticides and 5 antibiotics using different extraction procedures followed by GC-MS/MS and LC-MS/MS. Potential human health risks via the consumption of contaminated fish was also assessed. Of the 72 analyzed fish muscle samples; 86% and 21% were contaminated with pesticides and antibiotics, respectively. Chlorpyrifos (ranging from less then LOQ to 0.08 mg/kg) was the most frequently detected pesticide followed by p,p’-DDE (ranging from less then LOQ to 0.04 mg/kg) in 83 and 45% of the fish muscle samples, respectively. Nitrofurazone (ranging from 8.6 to 52 μg/kg) was the most frequently detected antibiotic, followed by nitrofurantoin (ranging from 1.1 to 2 μg/kg) and chloramphenicol (ranging from less then LOQ to 0.17 μg/kg). These antibiotics were found in 12, 6 and 5% of the fish muscle samples, respectively. The spatial distribution of the detected pesticides and antibiotics in fish samples along the Rosetta branch showed that the highest mean concentrations were found in the Sabal area, followed by samples from Tala and El-Rahawy. An investigation into seasonal variations revealed that the highest mean concentrations of pesticides and antibiotics in fish samples were detected in winter and spring, respectively. According to target hazard quotient (THQ) calculations for the detected pollutants in Nile tilapia muscle, all pollutants gave THQ values lower than 1, indicating that the consumption of this fish from the study sites is unlikely to cause any detrimental effects to consumers.Pinkwater Biosolve (BioSolve®) is one bioremediating chemical which has been widely used for cleanup of crude oil spill in Nigeria. It is a water-based formulation of nonionic surfactants and other specialty chemicals. The level of toxicity resulting from environmental exposure to this chemical has not been well understood. The level of expression of proinflammatory cytokines and histological changes in Gallus domesticus embryo were investigated. The embryo were pretreated with different doses of BioSolve, soil water from remediated soil sample, 10% soluble crude oil portion and a combination of the BioSolve with the soluble crude portion all constituted in normal saline solution. Reverse transcriptase PCR technique was used to assess the expression of hepatic proinflammatory cytokines. Histological examination was also carried out on liver fragments. The results showed that the pretreatment caused lesion on hepatocytes of all tested chick embryos except in the group administered with normal saline solution when compared with the normal control. The chick embryo exposed to 0.5 mg/kg BioSolve, 5% decanted soil water (v/v) obtained from crude oil remediated (using BioSolve) soil, and 10% (v/v) decanted crude oil remediated (using BioSolve) soil water all showed significant expression (at p less then 0.05) of IFNγ, TGFβ1, IL-1β, IL-2 and TNF. The group treated with 10% soluble portion of crude oil showed significant changes in their expression pattern when compared with the control; TNF was up regulated, while IL-1β, IFNγ and TGFβ1 were down regulated. Only TNF was upregulated at p less then 0.05 indicating the chances of soluble portion of crude oil causing cancer. IFNγ, TGFβ1, IL-1β and IL-2 were all down regulated significantly at p less then 0.05 due to exposure to a combination of 10% soluble crude and 0.036 mg/kg BioSolve. The combination of 10% soluble crude and 0.36 mg/kg BioSolve caused lethal effect to the developing chick embryo.Medicinal plant as herbal medicine is widely used to cure infectious diseases. Rubus fruticosus L (R. fruticosus) has been studied for its antimicrobial and cytotoxic activities. Different polarity leave extracts were prepared by using hexane, chloroform, ethyl acetate and hydro alcoholic solvents. Agar diffusion method has been used to assess the antibacterial activity against two gram-positive Enterococcus faecalis and Staphylococcus aureus and two gram-negative Escherichia coli and Haemophilus influenza bacterial strains. Cytotoxic activity was carried out against brine shrimp using the nauplii method (BSL). The results so obtained for various experiments demonstrates the total number of extracts produces moderate to strong antibacterial activity against the gram (+ and -). The best activity was discovered within hydro alcoholic upon all concentrations, whereas the inhibition zone exists within the range of 6-11 mm. In addition to that, the cytotoxic activity test confirms that hydro alcoholic extracts the maximum toxicity for values LC50 (4.