• The role of insulin receptor (IR) activated by hyperinsulinemia in obesity-induced kidney injury is not well understood. We hypothesized that activation of kidney proximal tubule epithelial IR contributes to obesity-induced kidney injury. We administered normal-fat diet (NFD) or high-fat diet (HFD) to control and kidney proximal tubule IR-knockout…[Read more]

  • 023). Overall 60-day mortality was 14.4% 23.8% (n = 24) in the AKI group versus 5% (n = 5) in the non-AKI group (HR 2.79 , p = 0.040); and 35.3% (n = 12) in the RRT group versus 10.2% (n = 17) in the non-RRT group, respectively (HR 2.21 , p = 0.047).

    AKI was common among critically ill COVID-19 patients and occurred early in association…[Read more]

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