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Johns Fabricius posted an update 6 months, 3 weeks ago
Conclusion Together, the results suggest that miscommunication both emerges and benefits from ambiguous and lexically dense utterances.
Prior research has suggested that higher levels of socioeconomic status (SES) may be linked with heightened mental illness stigma (MIS). It has been posited that this link is due to the resource-rich environment high-SES individuals live in, which predisposes them to seeing the certain phenomena as being more controllable in nature than low-SES individuals.
The current study intended to address the attributional mechanisms behind the SES-MIS link.
In a sample of 932 participants, we collected self-reported SES along with the controllability attributions and personal responsibility judgments participants make for individuals with mental illnesses.
Analyses indicated that SES was significantly associated with greater MIS levels, and that this link was significantly mediated by controllability attributions and personal responsibility judgments.
Findings suggest that high-SES individuals are more likely to see mental illness as due to internal, controllable factors, which leads to blaming the individual for mental illness onset and, ultimately, greater mental illness stigma. These results provide support for more socioeconomically diverse committees and panels where mental health funding decisions are made due to inherent attributional biases which may be present along the SES spectrum.
Findings suggest that high-SES individuals are more likely to see mental illness as due to internal, controllable factors, which leads to blaming the individual for mental illness onset and, ultimately, greater mental illness stigma. click here These results provide support for more socioeconomically diverse committees and panels where mental health funding decisions are made due to inherent attributional biases which may be present along the SES spectrum.
With increasing neuroimaging applications of contemporary three-dimensional
W fast spin echo (3D T1W FSE) sequences, it was aimed to reappraise the normal patterns of skull base facial nerve gadolinium enhancement.
Pre- and post-gadolinium 3D T1W fast spin echo imaging studies (
= 64) were retrospectively analysed in patients without suspected facial nerve pathology. Two independent observers scored the signal at each of six skull base facial nerve segments. Wilcoxon signed-rank test was used to compare changes in signal between pre- and post-gadolinium sequences at each location, and how this differed between proprietary sequences or between the pairs of facial nerves.
There was significant enhancement at the fundal canalicular (16%), geniculate ganglion (96%), tympanic (45%) and mastoid (38%) facial nerve segments (
< 0.05). Two different proprietary sequences demonstrated similar patterns of enhancement and there was symmetry between the two sides.
There is a differing pattern of normal facial nerve enhancement on contemporary 3D T1W FSE sequences compared to previous studies of 2D T1W SE imaging and fundal canalicular enhancement may be physiological.
This is the first study to evaluate patterns of normal facial nerve enhancement using contemporary 3D T1W FSE MRI sequences.
This is the first study to evaluate patterns of normal facial nerve enhancement using contemporary 3D T1W FSE MRI sequences.
This study aims to investigate the potential of DSPE-PEG polymers (DSPE-PEG-OH and DSPE-PEG-SH) on improving absorption of poorly absorbable macromolecules
intrapulmonary administration and underlying mechanism.
pulmonary absorption experiments were performed to investigate the absorption of model compounds after intrapulmonary administration to rats. The local membrane damage induced by these DSPE-PEG polymers were evaluated based on morphological observation of lung tissues and measurement of biological toxic markers in bronchoalveolar lavage fluid (BALF) postintrapulmonary delivery of DSPE-PEG polymers to rats. The underlying enhancement mechanism of these polymers was explored by investigating their effects on the pulmonary membrane fluidity and gene expression of tight junction associated proteins with fluorescence polarization and western blotting, respectively.
Intrapulmonary delivery of these DSPE-PEG polymers significantly enhanced absorptions of poorly absorbed model drugs and did not induon-associated proteins (ZO-1 and occludin), indicating the underlying mechanism by which these polymers exerted their absorption enhancing actions through pulmonary epithelial paracellular pathways. Thus, this study exhibited prospective potential of these DSPE-PEG polymers in developing into dosage forms with the aim to improve the poor bioavailability of some poorly absorbed macromolecular drugs.Leiomyomas are benign lesions of the uterine smooth muscles that contain various amounts of fibrous connective tissue. Hystrosalpingography is not a method of diagnosing uterine fibroids, and other methods such as ultrasound and MRI are preferred, but during hystrosalpingography, especially in infertile females, uterine fibroids may be seen frequently. Leiomyomas have a wide range of appearances depending on their number, size and location. Leiomyomas may enlarge, elongate, displace, distort or rotate the uterine cavity and can be detected by such changes showing in hysterosalpingograms. These changes may be symmetric or asymmetric. Leiomyomas may result in uterine atony which can be locolized or generalized. Leiomyomas also may appear as one or multiple filling defects in different sizes which can be smooth or irregular. Some of the noted findings may create similar and frequent appearances looking like some patterns in nature and can be considered “excellent signs” for better detecting and enabling differential diagnosis. This study aims to improve the process of training on the diagnostic appearances of leiomyomas in hysterosalpingography by aligning the images with patterns found in nature that can be easily remembered by radiologists.
The American Society for Radiation Oncology (ASTRO) produced an evidence-based guideline on radiation therapy (RT) for small-cell lung cancer (SCLC). Because of the relevance of this topic to ASCO membership, ASCO reviewed the guideline, applying a set of procedures and policies used to critically examine guidelines developed by other organizations.
The ASTRO guideline on RT for SCLC was reviewed for developmental rigor by methodologists. Then, an ASCO Expert Panel reviewed the content and the recommendations.
The ASCO Expert Panel determined that the recommendations from ASTRO guideline on RT for SCLC, published in June 2020, are clear, thorough, and based upon the most relevant scientific evidence. ASCO endorsed ASTRO guideline on RT for SCLC with a few discussion points.
Recommendations addressed thoracic radiotherapy for limited-stage SCLC, role of stereotactic body radiotherapy in stage I or II node-negative SCLC, prophylactic cranial radiotherapy, and thoracic consolidation for extensive-stage SCLC.