Humphrey Ralston

This represents a waste of resources and a loss of opportunity for other drugs to be properly evaluated. In the context of emergency, rigorous trials are more than ever needed in order to have, as soon as possible, reliable data on drugs that are possibly effective against the disease. Meanwhile, serious adverse drug reactions have been reported…[Read more]

36 h for bowel sounds , 48 h vs. 72 h for passage of flatus , and 84 h vs. 96 for passage of stools ). Perioperative complication rate (12 patients (44.4%) vs. 14 (51.9%), P = 0.786) was similar. Conclusions ERAS protocol leads to faster bowel recovery compared to conventional care in patients undergoing open RC but fails to demonstrate a…[Read more]

Patients who received this combination therapy had a higher grade ≥ 3 adverse event rate more than those who received AI monotherapy (Risk Difference 43%, 95%CI 0.39-0.47). Fulvestrant 500 mg alone significantly improved PFS (risk ratio 0.85, 95%CI 0.72-0.98), but ORR and CBR were similar to those of anastrozole alone. CONCLUSION In the first…[Read more]