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Mattingly Collins posted an update 6 months ago
Outreach initiatives to minimize the impact of treatment barriers, coupled with offering separate treatment protocols and facilities, will encourage people who use ATS to seek treatment voluntarily.The ergogenic effects of carbohydrate (CHO) and caffeine (CAF) mouth rinse (MR) methods on anaerobic performance remains unclear. Therefore, the aim of this study was to investigate the effects of CHO, CAF, and CHO + CAF combination solutions in mouth on repeated vertical jumping (RVJ) performance in highly trained male athletes. Eight male athletes (mean age 22 years) underwent test sessions four times with minimum 24-h intervals under fasting conditions. Participants rinsed their mouths with four different 25-ml solutions, namely, CHO (6.4% maltodextrin = 1.6 g), CAF (1.2% caffeine = 300 mg), placebo (PLA, saccharin), or CHO + CAF (6.4%+1.2%) combination, for 10 s and performed a 30-s RVJ test twice with a 5-min interval. Peak power output, vertical jump height, blood lactate level, fatigue index, and rate of perceived exertion of the RVJ tests for different intervention sessions were compared. The statistical significance level was set at p ≤ 0.05. Analyses demonstrated that CHO- (Δ 3.4), CAF- (Δ -0.8), anefore, the issue is still worth to be a potential topic for further research.The emergence of 2019 novel Coronavirus (COVID-19 or 2019-nCoV) has caused significant global morbidity and mortality with no consensus specific treatment. We tested the hypothesis that FDA-approved antiretrovirals, antibiotics, and antimalarials will effectively inhibit COVID-19 two major drug targets, coronavirus nucleocapsid protein (NP) and hemagglutinin-esterase (HE). To test this hypothesis, we carried out a phylogenic analysis of coronavirus genome to understand the origins of NP and HE, and also modeled the proteins before molecular docking, druglikeness, toxicity assessment, molecular dynamics simulation (MDS) and ligand-based pharmacophore modeling of the selected FDA-approved drugs. Our models for NP and HE had over 95% identity with templates 5EPW and 3CL5 respectively in the PDB database, with majority of the amino acids occupying acceptable regions. The active sites of the proteins contained conserved residues that were involved in ligand binding. Lopinavir and ritonavir possessed greater binding affinities for NP and HE relative to remdesivir, while levofloxacin and hydroxychloroquine were the most notable among the other classes of drugs. The Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), Radius of gyration (Rg), and binding energy values obtained after 100 ns of MDS revealed good stability of these compounds in the binding sites of the proteins while important pharmacophore features were also identified. The study showed that COVID-19 likely originated from bat, owing to the over 90% genomic similarity observed, and that lopinavir, levofloxacin, and hydroxychloroquine might serve as potential anti-COVID-19 lead molecules for additional optimization and drug development for the treatment of COVID-19.Communicated by Ramaswamy H. Sarma.With the outbreak of the COVID-19 worldwide pandemic, many countries have imposed lockdowns which have caused an increase in Internet use. As large-scale disasters may have an impact on addictions, a review on Internet-based addictive behaviors seems necessary. The goals of this review are to find whether Internet-based addictive behaviors have increased during the pandemic and to define the main reasons for this increase. The systematic search was conducted in Google Scholar, Science Direct, PsycINFO, and PubMed in October of 2020, to determine the current evidence and observations concerning the Internet-based addictive behaviors amid COVID-19. Studies were included if they considered the Internet-based addictive behaviors during the current pandemic. We used all the names of the coronavirus 2 (SARS-CoV2 previously 2019 nCoV), the name of the coronavirus disease 2019 (COVID-19), and common Internet-based addictive behaviors, namely Internet addiction, online gaming disorder, online gambling disorder, pornography use, and smartphone use disorder. The study design is PEOs, finding if individuals’ exposure to the COVID-19 pandemic has caused an increase in Internet-based addictive behaviors. The quality of the studies was assessed independently by two authors using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. The articles found in this review proved an increase in Internet-based addictive behaviors during the COVID-19 pandemic mostly due to financial hardships, isolation, problematic substance use, and mental health issues such as depression, anxiety, and stress. Effective interventions should be scaled up to prevent and reduce online addictive behaviors, as well as accessible guidelines, particularly for adolescents.Introduction. The ventral premotor area (VPM) plays a crucial role in executing various aspects of motor control. These include hand reaching, joint coordination, and direction of movement in space. While many studies discuss the VPM and its relationship to the rest of the motor network, there is minimal literature examining the connectivity of the VPM outside of the motor network. Using region-based fMRI studies, we built a neuroanatomical model to account for these extra-motor connections.Methods. Thirty region-based fMRI studies were used to generate an activation likelihood estimation (ALE) using BrainMap software. Cortical parcellations overlapping the ALE were used to construct a preliminary model of the VPM connections outside the motor network. Diffusion spectrum imaging (DSI)-based fiber tractography was performed to determine the connectivity between cortical parcellations in both hemispheres, and a laterality index (LI) was calculated with resultant tract volumes. The resulting connections were described using the cortical parcellation scheme developed by the Human Connectome Project (HCP).Results. Four cortical regions were found to comprise the VPM. These four regions included 6v, 4, 3b, and 3a. Across mapped brains, these areas showed consistent interconnections between each other. Additionally, ipsilateral connections to the primary motor cortex, supplementary motor area, and dorsal premotor cortex were demonstrated. Tozasertib purchase Inter-hemispheric asymmetries were identified, especially with areas 1, 55b, and MI connecting to the ipsilateral VPM regions.Conclusion. We describe a preliminary cortical model for the underlying connectivity of the ventral premotor area. Future studies should further characterize the neuroanatomic underpinnings of this network for neurosurgical applications.
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