• Hassan Staal posted an update 6 months ago

    Currently, clinical treatment for temozolomide (TMZ)-resistant glioblastoma multiforme (GBM) is still a difficult problem. The aim of this paper is to set up a new GBM-targeted drug delivery system to treat TMZ-resistant GBM. Zoledronate (ZOL) not only induces apoptosis of TMZ-resistant GBM cells by down-regulation of farnesyl pyrophosphate…[Read more]

  • Hassan Staal posted an update 6 months ago

    PorphyStruct, a new digital tool for the analysis of non-planar distortion modes of different porphyrinoids, and its application to corrole structures is reported. The program makes use of the normal-coordinate structure decomposition technique (NSD) and employs sets of normal modes equivalent to those established for porphyrins in order to…[Read more]

  • There is evidence of episodic positive diversifying selection shaping ORs in expanded subfamilies. Values of omega (dN/dS) are higher among 9-exon ORs compared to other OR subfamilies. Within the Polistes OR gene tree, branches in the 9-exon OR clade experience relaxed negative (relaxed purifying) selection relative to other branches in the tree.…[Read more]

  • Hassan Staal became a registered member 6 months, 1 week ago