• While transfer of WT T-cells into RAG -/-TYK2 KE hosts induced colitis, TYK2 KE T-cells transferred into RAG1 -/-TYK2 KErecipients failed to do so. Ex vivo analysis showed a decrease in colon tissue Th1 cells and an increase in Th17 cells upon transfer of TYK2 KE-CD45RB high cells. In human antigen triggered T-cells, TYK2i displayed reduced Th1…[Read more]

  • While transfer of WT T-cells into RAG -/-TYK2 KE hosts induced colitis, TYK2 KE T-cells transferred into RAG1 -/-TYK2 KErecipients failed to do so. Ex vivo analysis showed a decrease in colon tissue Th1 cells and an increase in Th17 cells upon transfer of TYK2 KE-CD45RB high cells. In human antigen triggered T-cells, TYK2i displayed reduced Th1…[Read more]

  • We described protein A immunoadsorption combination with immunosuppressive treatment improved rapidly a patient with Neuropsychiatric systemic lupus erythematosus.Bilateral shoulder adhesive capsulitis may develop in association with the administration of an influenza vaccine. Vaccine administration should utilize proper technique to avoid…[Read more]

  • We described protein A immunoadsorption combination with immunosuppressive treatment improved rapidly a patient with Neuropsychiatric systemic lupus erythematosus.Bilateral shoulder adhesive capsulitis may develop in association with the administration of an influenza vaccine. Vaccine administration should utilize proper technique to avoid…[Read more]

  • We described protein A immunoadsorption combination with immunosuppressive treatment improved rapidly a patient with Neuropsychiatric systemic lupus erythematosus.Bilateral shoulder adhesive capsulitis may develop in association with the administration of an influenza vaccine. Vaccine administration should utilize proper technique to avoid…[Read more]

  • We described protein A immunoadsorption combination with immunosuppressive treatment improved rapidly a patient with Neuropsychiatric systemic lupus erythematosus.Bilateral shoulder adhesive capsulitis may develop in association with the administration of an influenza vaccine. Vaccine administration should utilize proper technique to avoid…[Read more]

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