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Berthelsen Dorsey posted an update 6 months, 3 weeks ago
9±5.0 days earlier in UAE. Conclusions A significant proportion of patients hospitalized for MRSA cSSTI could be eligible for ES or ED opportunities, resulting in potential for reductions in IV and bed days.Objective To determine whether coating prosthesis liners with a 5% aluminium zirconium tetrachlorohydrate antiperspirant solution (AZCH) reduces local sweating on the thigh. Design Double-blinded counter-balanced crossover design METHODS Fourteen able-bodied participants (age 28±5 y; body mass 73.9±7.9kg, height 1.73±0.09m; peak oxygen consumption 50.7±9.1 mlO2⋅kg-1⋅min-1) simultaneously wore a prosthesis liner on each leg, one treated with AZCH and one untreated, for four days prior to running at 50% of VO2peak for 60min in a temperate (23.7±0.7°C and 42.2±2.6% relative humidity) or hot (34.0±1.6°C and 40.8±6.1% relative humidity) environment. Rectal temperature (Tre) and whole-body sweat rates (WBSR) were measured to characterize thermal strain. Local sweat rate (LSR) was measured bilaterally underneath the liners, continuously, and heat-activated-sweat gland density (HASGD) was measured bilaterally every 15min. Results In temperate condition, the mean change in Tre was 1.2±0.4°C and WBSR was 723±129g⋅h-1, whereas in the hot condition, change in Tre was 1.2±0.5°C and WBSR was 911±231g⋅h-1. In the temperate condition, AZCH treatment did not alter LSR (treated 0.50±0.17 mg·cm-2min-1, untreated 0.50±0.17 mg·cm-2min-1; P=0.87) or HASGD (treated 54±14 glands·cm-2, untreated 55±14 glands·cm-2; P=0.38). In the hot condition, AZCH treatment paradoxically increased LSR (treated 0.88±0.38 mg·cm-2min-1, untreated 0.74±0.28 mg·cm-2min-1; P=0.04) but not HASGD (treated 52±17 glands·cm-2, untreated 48±19 glands·cm-2; P=0.77). Conclusion These results indicate coating prosthesis liners with 5% AZCH is ineffective at reducing local sweating.Objectives The purpose of this study was to examine whether the use of machine learning improved the ability of a neuromuscular screen to identify injury risk factors in elite male youth football players. Design Prospective cohort study. Methods 355 elite youth football players aged 10-18 years old completed a prospective pre-season neuromuscular screen that included anthropometric measures of size, as well as single leg countermovement jump (SLCMJ), single leg hop for distance (SLHD), 75% hop distance and stick (75%Hop), Y-balance anterior reach and tuck jump assessment. Injury incidence was monitored over one competitive season. Risk profiling was assessed using traditional regression analyses and compared to supervised machine learning algorithms constructed using decision trees. H 89 cell line Results Using continuous data, multivariate logistic analysis identified SLCMJ asymmetry as the sole significant predictor of injury (OR 0.94, 0.92-0.97, p less then 0.001), with a specificity of 97.7% and sensitivity of 15.2% giving an AUC of 0.661. The best performing decision tree model provided a specificity of 74.2% and sensitivity of 55.6% with an AUC of 0.663. All variables contributed to the final machine model, with asymmetry in the SLCMJ, 75%Hop and Y-balance, plus tuck jump knee valgus and anthropometrics being the most frequent contributors. Conclusions Although both statistical methods reported similar accuracy, logistic regression provided very low sensitivity and only identified a single neuromuscular injury risk factor. The machine learning model provided much improved sensitivity to predict injury and identified interactions of asymmetry, knee valgus angle and body size as contributing factors to an injurious profile in youth football players.Date of birth 29/07/1993; gender female. Pre-treatment documents 19 years 2 months old 29/07/1993. Diagnosis Skeletal class II with mandibular laterognathia and retrusion, hypodivergent facial pattern; class II division 1, transverse maxillary deficiency with left unilateral posterior cross bite; missing teeth before treatment 18 28 38 48. Treatment planning Orthosurgical treatment (bimaxillary surgery); Bimaxillary lingual fixed appliances. Duration of active treatment 2 years. Post-treatment documents 22 years 5 months old; 09/01/2015. Post-retention documents 05/01/2016; 23 years 5 months old. Retention period 3 years.Aeromonas hydrophila 4AK4 normally produces the copolymer of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx) using lauric acid as the carbon source. In this study we reported the metabolic engineering of A. hydrophila 4AK4 for the production of polyhydroxyalkanoate (PHA) using acetate as a main carbon source. Recombinant A. hydrophila overexpressing β-ketothiolase and acetoacetyl-CoA reductase could accumulate poly-3-hydroxybutyrate (PHB) from acetate with a polymer content of 1.39 wt%. Further overexpression of acetate kinase/phosphotransacetylase and acetyl-CoA synthetase improved PHB content to 8.75 wt% and 19.82 wt%, respectively. When acetate and propionate were simultaneously supplied as carbon sources, the engineered A. hydrophila overexpressing β-ketothiolase, acetoacetyl-CoA reductase, and acetyl-CoA synthetase was found able to produce the copolymer of 3-hydroxybutyrate and 3-hydroxyvalerate (PHBV). The recombinant grew to 3.79 g/L cell dry weight (CDW) containing 15.02 wt% PHBV. Our proposed metabolic engineering strategies illustrate the feasibility for producing PHA from acetate by A. hydrophila.The lungs are the most common disease site of nontuberculous mycobacteria (NTM). However, the isolation of NTM in a respiratory specimen does not indicate lung disease (LD). Differentiation between NTM colonization and NTM-LD remains challenging. In this brief review, we summarize the clinical impact of NTM-LD on morbidity and mortality in high-risk populations. The diagnosis criteria for NTM-LD-including clinical features, radiological presentations, and microbiological evidence-are also reviewed, according to the latest American Thoracic Society (ATS)/Infectious Disease Society of America (IDSA) guideline and the British Thoracic Society (BTS) guideline. However, the diagnosis of NTM-LD does not necessitate the initiation of anti-NTM treatment. Both environmental, host, and bacterial factors should be considered to identify patients that require NTM-LD treatment.
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