McGuire Rich

its macrophage migration. V.One of the most important self-defense strategies employed by bacteria to resist the action of antibiotics is a biofilm formation upon the infected surface. Thus, there is an urgent need to explore novel candidates that have potent antibacterial and anti-biofilm effects to tackle this challenge. In this endeavor, we…[Read more]

The development and dissemination of antibiotic-resistant bacterial pathogens is a growing global threat to public health. Novel compounds and/or therapeutic strategies are required to face the challenge posed, in particular, by Gram-negative bacteria. Here we assess the combined effect of potent cell-wall synthesis inhibitors with either natural…[Read more]

Compared with the control, hypoxic MSCs reduced brain water content significantly (p < 0.05). Tuvusertib order Both hypoxic and normoxic MSCs downregulated the expression of MMP9 and normalized AQP4 distribution to astrocyte end feet.

Our preliminary study showed that topical application of hypoxic MSCs suppressed both vasogenic and…[Read more]

Hence, an extensive application of the drug repurposing approach will not only help to fight the current pandemics more efficiently but also predict and prepare for newly emerging viral infections. In this review, we discuss in detail the drug repurposing approach and its advancements related to viral infections such as Human Immunodeficiency…[Read more]