Boye Herring

Pulmonary arterial hypertension (PAH) is a multifactorial disease characterized by pulmonary arterial vasoconstriction and remodeling. Src family tyrosine kinases, including Fyn, play critical roles in vascular remodeling via the inhibition of STAT3 signaling. EPA is known to inhibit Fyn kinase activity. This study investigated the therapeutic…[Read more]

Most patients with ophthalmic sarcoidosis have evidence of systemic involvement at the time of the initial examination and have bilateral ocular presentation. We present here the unique case of a 67-year-old man with unilateral 360-degree choroidal detachment and serous retinal detachment as an ocular presentation of sarcoidosis.BACKGROUND…[Read more]

ocs3 deficient mice and predicted patient survival. The Cox proportional hazards model identified the combinations of SOCS1 or SOCS3 with CXCL8 and DAB2 as highly predictive.

SOCS1 expression in HCC has an independent prognostic value whereas SOCS3 expression does not. The predictive potential of SOCS1 expression is increased when combined…[Read more]

This integrated record offers the opportunity to explore the daily progression of the most costly, damaging, and deadly events in the U.S., particularly for wildfires.Serial X-ray crystallography at free-electron lasers allows to solve biomolecular structures from sub-micron-sized crystals. However, beam time at these facilities is scarce, and…[Read more]

38 (95% CI 0.28-0.52) for intermediate CRF (range 7.7-10.6 METs) and 0.17 (95% CI 0.11-0.27) for high CRF (range 10.7-22.0 METs). The corresponding HRs were 0.40 (95% CI 0.19-0.86) and 0.41 (95% CI 0.16-1.05) for cardiovascular mortality and 0.40 (95% CI 0.26-0.60) and 0.16 (95% CI 0.09-0.28) for cancer mortality, respectively. The adjusted risk…[Read more]