Egan Purcell

Tumor heterogeneity is a major cause of therapeutic resistance. Immunotherapy may exploit alternative vulnerabilities of drug-resistant cells, where tumor-specific human leukocyte antigen (HLA) peptide ligands are promising leads to invoke targeted anti-tumor responses. Here, we investigate the variability in HLA class I peptide presentation…[Read more]

The difference between the genders’ suicide rate changed significantly at the onset of recession, as the rate for men increased and the rate for women decreased.

The Danish social welfare model might have prevented social disintegration and suicide among unemployed, and suicide prevention programmes might have prevented deaths among…[Read more]

8% vs 8.1%) were seen in AMI admissions with respiratory infections. Coronary angiography (41.4% vs 65.6%, p less then 0.001) and percutaneous coronary intervention (20.7% vs 43.5%, p less then 0.001) were used less commonly in those with respiratory infections. Admissions with respiratory infections had higher in-hospital mortality (14.5% vs…[Read more]

Administration of ECa 233 was found to be significantly associated with an increase of choline, an endogenous metabolite with documented benefits for learning and memory. Therefore, ECa 233 may be useful in mitigating cognitive impairment, through its role in modulating human metabolites.The rapid spread of the Coronavirus (COVID-19) confronts…[Read more]

Administration of ECa 233 was found to be significantly associated with an increase of choline, an endogenous metabolite with documented benefits for learning and memory. Therefore, ECa 233 may be useful in mitigating cognitive impairment, through its role in modulating human metabolites.The rapid spread of the Coronavirus (COVID-19) confronts…[Read more]

This paper aims to investigate detailed mechanical interactions between the pulmonary haemodynamics and left heart function in pathophysiological situations (e.g. atrial fibrillation and acute mitral regurgitation). This is achieved by developing a complex computational framework for a coupled pulmonary circulation, left atrium and mitral valve…[Read more]

of parasympathetic activity on the heart, to the same extent in either vestibular or visual stimulation. These results indicate that visual flow in VR can be used as a non-electrical method for vagus nerve inhibition without the need for body motion in the treatment of disorders with vagal overactivity. The findings are also important for VR and…[Read more]

87 95% CI -3.83 to -0.09; P = 0.06;I2= 99%), and HbA1c (SMD -1.92; 95% CI – 3.03 to -0.81; P = 0.0007; I2 = 92%) in patients with T2DM. No such effect was found for SOD (SMD -1.01; 95% CI -4.41 to 2.38; P = 0.56; I2= 99%).

The available evidence suggests that yoga reduces MDA, fasting plasma glucose and HbA1C, and thus would be beneficial…[Read more]

Similarly, PSL treatment at 100 µg L-1 that significantly induced cat expression in gills or sod1 in visceral mass showed repressed mRNA levels when combined with As (reduction of 2222% and 34%, respectively, compared to the control). This study suggested a protective effect of the interaction between NPs and As, possibly by decreasing both…[Read more]

The objective of this study was to characterize the changes in timeliness and completeness of disease case reporting in Texas in response to an increasing number of foodborne illnesses and high-consequence infectious disease investigations and the Texas Department of State Health Services’ new state-funded epidemiologist (SFE) program.

We…[Read more]

The ability to produce force rapidly has the potential to directly influence sprinting performance through changes in stride length and stride frequency. This ability is commonly referred to as the rate of force development (RFD). For this reason, many elite sprinters follow a combined program consisting of resistance training and sprint training.…[Read more]