• Cancer cells are characterized by the Warburg effect, a shift from mitochondrial respiration to oxidative glycolysis. We report here the crucial role of cyclin D1 in promoting this effect in a cyclin-dependent kinase (CDK)4/6-independent manner in multiple myeloma (MM) cells. We show that the cyclin D1 oncoprotein targets hexokinase 2 (HK2), a…[Read more]

  • 0001) and postoperatively ( p   less then  0.0001), as well as reduced postoperative pain starting from day 0 ( p   less then  0.001), which continued until postoperative day 2 ( p   less then  0.001). Conclusion  Music therapy is an effective adjunct in the control of anxiety and postoperative pain following nasal septal surgery.Neuro…[Read more]

  • Through regression analyses, PGD severity was predicted by low education, being unemployed, long duration of a marital relationship, and traumatic death in the French sample, whereas it was predicted by being male and highly educated in the Togolese sample. AZD8797 chemical structure Both groups only shared a recent bereavement period as a common…[Read more]

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