Casey Burnett

Moreover, genetic and pathophysiologic inhibition of the HIF-2α-NEU3-ceramide pathway can alleviate insulin resistance, suggesting that these could be potential drug targets for the treatment of metabolic diseases. Herein, the effects of hypoxia and ceramide, especially in the intestine, on metabolic diseases are summarized.Hepatitis B virus…[Read more]

During the last century, our battle against cancer has been inaugurated upon three main approaches; surgery, radiation and chemotherapy. The latest findings on the effectiveness of immunotherapy in cancer management offer a ray of hope after decades of research and studies on the best treatment methods. Immunotherapy has proven effective in the…[Read more]

Osteoarthritis and inflammatory arthropathies are a cause of significant morbidity globally. New research elucidating the metabolic derangements associated with a variety of bone and joint disorders implicates various local and systemic metabolites, which further elucidate the underlying molecular mechanisms associated with these destructive…[Read more]

For example, exposure to aflatoxin, heavy alcohol drinking, possibly dairy (not including yogurt) intake increase, while intake of coffee, fish, and tea, light-to-moderate alcohol drinking, and several healthy dietary patterns (e.g., Alternative Healthy Eating Index) may decrease liver cancer risk. Future studies with large sample size and…[Read more]

001, total multivariable model R2=0.281). During median (interquartile range) follow-up for 8.3 (7.8-8.9) years, 364 patients died (5.8%), of whom 95 (26.1%) died from a cardiovascular cause. In multivariable Cox proportional hazard models, each 60 minutes decrease in serum T50 was independently associated with a higher risk of cardiovascular…[Read more]

Schizophrenia is associated with high health care resource utilization and treatment costs.

This study compared treatment patterns, health care resource utilization, and medical costs before and after a switch from oral antipsychotic drug (risperidone or paliperidone ) therapy to the long-acting injectable once-monthly paliperidone…[Read more]

PUFAs did not remarkably affect social behavior and hormone concentrations, but enabled the strongest body mass gain, which probably resulted from an energetic advantage. Neither sociopositive nor agonistic behaviors explained age-specific differences in hormone concentrations between groups. However, a high number of subdominant individuals and…[Read more]

TWIST1 level was up-regulated by nearly 5-fold and 7.4-fold in GFP-hTWIST1 KYSE-30 and YM-1 cells compared to GFP control cells, respectively. Interestingly, this enforced expression of TWIST1 subsequently caused significant overexpression of transcripts for selected MMP genes in GFP-hTWIST1 in comparison with GFP control cells in both ESCC cell…[Read more]

TWIST1 level was up-regulated by nearly 5-fold and 7.4-fold in GFP-hTWIST1 KYSE-30 and YM-1 cells compared to GFP control cells, respectively. Interestingly, this enforced expression of TWIST1 subsequently caused significant overexpression of transcripts for selected MMP genes in GFP-hTWIST1 in comparison with GFP control cells in both ESCC cell…[Read more]

Aim To establish the prevalence of refractive errors in preschool and school children between 4 and 15 years of age, living in Tuzla, Bosnia and Herzegovina. Methods Children from all elementary schools in the city of Tuzla and as well from eight day-care centres were screened for refractive errors in the period 2015-2019. Any child, who failed to…[Read more]

SCHLUSSFOLGERUNG UND KLINISCHE RELEVANZ Die Ergebnisse erlauben erstmals quantitative Voraussagen zur Interaktion von Fischbesatz und Sauerstoffhaushalt in eingerichteten handelsüblichen Standardaquarien. Selbst unter den im Versuch eingestellten Bedingungen (erhöhter Besatz, mangelnde Filterhygiene, übermäßige Futtergabe) erwiesen sich alle Aqua…[Read more]