• Brask Birch posted an update 6 months, 2 weeks ago

    The demonstrated highly polarized lasing output and wavelength-tunable capacity of the proposed device scheme in MIR spectral range opens up promising opportunities for a broad array of applications in polarization-resolved IR imaging, range-finding, and free space quantum communications. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Herein, magnetite/graphene oxide hybrid (MGO) was facilely synthesized and analyzed by various techniques such as X-ray diffraction spectroscopy, Fourier-transform infrared spectroscopy, transmission electron microscopy, Brunauer, Emmett and Teller surface area analyzer, and Raman spectroscopy. A computational density functional theory (DFT) has been applied for the first time to determine the removal mechanism of zinc (Zn2+ ), nickel (Ni2+ ), and chromium (Cr6+ ) hydrates onto the prepared MGO. The adsorption binding energy and geometries of the metal hydrates with oxygen functional group (i.e. selleckchem hydroxyl, epoxide, carboxylic, carbonyl groups, and magnetite on the MGO surface) were estimated. The complexes configurations comprised via sitting the metal ion perpendicular and above the MGO surface. The zinc hydrate portended to bind more strongly than Ni2+ and Cr6+ . Zinc hydrate is favorably to coordinate with hydroxyl and carboxylic group than the other functional groups. The pseudo-second order kinetic and Langmuir isotherm models are well convenient for kinetics and isotherm sorption process, respectively. The results determined that the sorption of heavy metals by nanostructure MGO was observed in the following order zinc > nickel > chromium as revealed by the DFT computations. The maximum adsorption capacity of Zn2+ , Ni2+ , and Cr6+ were 333 mg g-1 , 250 mg g-1 , and 200 mg g-1 , respectively. Thermodynamic constants depicted that the sorption process is naturally instantaneous and exothermic. The calculated predicted results are fitted with the experimental results. This article is protected by copyright. All rights reserved.In this communication, we report the straightforward synthesis of unprecedented electron-acceptors based on dicationic P-containing PAHs (Polycyclic Aromatic Hydrocarbons) based on copper mediated radical approach. In these systems, two phosphoniums are connected through various PAHs backbones. The impact of π-extension on both the optical and redox properties is investigated using a joint experimental (UV-Vis absorption, fluorescence and cyclic voltammetry) and theoretical approach (DFT calculations). Finally, (spectro)-electrochemical studies prove that these compounds possess three redox states and EPR studies confirms the in situ formation of an organic radical delocalized on the PAH backbone. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.The bone marrow (BM) microenvironment/niche plays a key role in regulating hematopoietic stem and progenitor cell (HSPC) activities; however, mechanisms regulating niche cell function are not well understood. In this study, we show that niche intrinsic expression of the CXCR4 chemokine receptor critically regulates HSPC maintenance during steady state, and promotes early hematopoietic regeneration after myeloablative irradiation. At steady state, chimeric mice with wild-type (WT) HSPC and marrow stroma that lack CXCR4 show decreased HSPC quiescence, and their repopulation capacity was markedly reduced. Mesenchymal stromal cells (MSC) were significantly reduced in the BM of CXCR4 deficient mice, which was accompanied by decreased levels of the HSPC supporting factors stromal cell-derived factor-1 (SDF-1) and stem cell factor (SCF). CXCR4 also plays a crucial role in survival and restoration of BM stromal cells after myeloablative irradiation, where loss of BM stromal cells was more severe in CXCR4-deficient mice compared to WT mice. In addition, transplantation of WT donor HSPC into CXCR4-deficient recipient mice demonstrated reduced HSPC homing and early hematopoietic reconstitution. We found that CXCR4 signaling attenuates irradiation-induced BM stromal cell loss by upregulating the expression of the antiapoptotic protein Survivin via the PI3K pathway. Our study suggests that SDF-1-CXCR4 signaling in the stromal microenvironment cells plays a crucial role in maintenance of HSPCs during homeostasis, and promotes niche regeneration and early hematopoietic reconstitution after transplantation. Modulation of CXCR4 signaling in the HSPC microenvironment could be a means to enhance hematopoietic recovery after clinical hematopoietic cell transplantation. ©AlphaMed Press 2020.Sustainable management of wildlife populations can be aided by building models that both identify current drivers of natural dynamics and provide near-term predictions of future states. We employed a Strategic Foresight Protocol (SFP) involving stakeholders to decide the purpose and structure of a dynamic state-space model for the population dynamics of the willow ptarmigan – a popular game species in Norway. Based on local knowledge of stakeholders, it was decided that the model should include food web interactions and climatic drivers to provide explanatory predictions. Modelling confirmed observations from stakeholders that climate change impacts ptarmigan populations negatively through intensified outbreaks of insect defoliators and later onset of winter. Stakeholders also decided that the model should provide anticipatory predictions. The ability to forecast population density ahead of the harvest season was valued by the stakeholders as it provides the management extra time to consider appropriate harvest regulations and communicate with hunters, prior to the hunting season. Overall, exploring potential drivers and predicting short-term future states, facilitate collaborative learning and refined data collection, monitoring designs and management priorities. Our experience from adapting a SFP to a management target with inherently complex dynamics and drivers of environmental change, is that an open, flexible, and iterative process, rather than a rigid step-wise protocol, facilitates rapid learning, trust, and legitimacy. This article is protected by copyright. All rights reserved.

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