• Goodwin Povlsen posted an update 6 months, 2 weeks ago

    tudies is recommended and expected.

    Despite meta-analytic results, gender and upper-secondary school would be unethical students’ entry selection criteria. Final upper-secondary school grades should be considered for this scope and purpose. Conflicting and limited evidence found for other factors, such as students’ background, suggested the influence of local contexts on the phenomenon and its investigation. Investigating the role of modifiable individual variables, such as empathy and critical thinking, could contribute to the open debate about students’ entry selection strategies. An improvement in methodological quality of future studies is recommended and expected.

    Qualified and student nurses remain at the forefront of dealing with, and reporting, patient safety events or incidents. There has been limited exploration of whether and how the patient’s perspective is represented by staff or student nurses using formal reporting systems.

    The overall aim of the study was to explore the student nurses’ experiences in practice of patient safety events they were themselves directly or indirectly involved in. This specifically explored the subsequent reporting and inclusion of the patient perspectives that may or may not have taken place.

    A qualitative approach to this research was selected using the principles of thematic analysis to analyse data gathered from focus groups of student nurses across all year groups.

    Three universities participated in the study located in the north east, south east and east of England.

    Student nurses from across the year groups attended focus groups.

    Following ethical approval and informed consent, participants took part in focus grourkforce that see the benefit of learning from those we care for.Non-aromatic fluorescent materials with inherent visible light emission have received widespread attention. In this work, a biomimetic fluorescent molecule CA-AEP with a dipeptide structure is introduced. CA-AEP will emit bright biomimetic fluorescence in aqueous solutions by adjusting the pH, which has never been reported. This unique luminescent characteristic can be rationalized by the clustering-triggered emission (CTE) mechanism. In addition, CA-AEP can be used to monitor the maximum dynamic pH in the alkaline range of aqueous systems. Finally, the cytotoxicity assay to A549 cells showed that CA-AEP was non-toxic. Therefore, this work provides a new type of luminogen, which has potential application prospects in the field of environmental monitoring and cell biology.In this paper, we proposed the technique of Natural Logarithm Wavelength Modulation Spectroscopy (ln-WMS). Unlike conventional WMS, the amplitudes of the harmonics are linear to the absorbance regardless how large it is. The treating method used in ln-WMS is taking the natural logarithm of the transmitted intensity. The key to ln-WMS is to find out the demodulation phase. We introduced the η-seeking algorithm, which works to find the demodulation phase η so that the 1st harmonic of the unabsorbed intensity comes to zero. Then the nth harmonic of the absorbed intensity is demodulated at phase nη. With simulations, we validated the effectiveness of ln-WMS as well as illustrated the shapes of 1st, 2nd and 3rd harmonics. Then we utilized ln-WMS for measuring water vapor experimentally. selleck It turns out that the linearity is established between the amplitudes of the 1st, 2nd and 3rd harmonics and concentration, although the absorbance is as large as 0.76. We evaluated the stability of the system with coefficient of variation and Allan deviation analysis, proved the effectiveness of the η-seeking algorithm and investigated how the modulation amplitude influenced the amplitudes of the harmonics.In this paper, a rhodamine derivative was synthesized as a probe for Hg(II) detection. Its spectral response and sensing mechanism towards Hg(II) were discussed carefully. It was found that its absorption and emission were increased by Hg(II), via a direct bonding stoichiometry of 11. Its association constant was determined with absorption titration as 2.59 × 105 M-1, which suggested a coordination procedure between Hg(II) and this rhodamine probe. It showed good selectivity towards Hg(II) over competing metal cations, no increased emission or absorption was observed in the presence of interfering metal cations. It was then covalently grafted onto silica (SiO2)-encapsulated upconversion nanoparticles (UCNPs). Upon near-infrared (NIR) excitation (980 nm), RHO accepted energy from these UCNPs through a FRET (fluorescence resonance energy transfer) procedure, quenching their upconversion emission. A sensing response towards Hg(II) was thus constructed. Good linearity and selectivity were still preserved in this composite sample. On the other hand, this work found a different phenomenon from literature cases, which was the emission absence of rhodamine emission in this composite structure. Detailed analysis suggested that rhodamine emission absence was caused by its self-quenching effect.Methicillin resistant Staphylococcus aureus (MRSA) constitute a serious health care problem worldwide. This study addresses the effect of β-lactam treatment on the ability of clinically relevant MRSA strains to induce IL-12 and IL-23. MRSA strains induced a dose-dependent IL-12 response in murine bone-marrow-derived dendritic cells that was dependent on endocytosis and acidic degradation. Facilitated induction of IL-12 (but not of IL-23) called for activation of the MAP kinase JNK, and was suppressed by p38. Compromised peptidoglycan structure in cefoxitin-treated bacteria – as denoted by increased sensitivity to mutanolysin -caused a shift from IL-12 towards IL-23. Moreover, cefoxitin treatment of MRSA led to a p38 MAPK-dependent early up-regulation of Dual Specificity Phosphatase (DUSP)-1. Compared to common MRSA, characteristics associated with a persister phenotype increased intracellular survival and upon cefoxitin treatment, the peptidoglycan was not equally compromised and the cytokine induction still required phagosomal acidification. Together, these data demonstrate that β-lactam treatment changes the MRSA-induced IL-12/IL-23 pattern determined by the activation of JNK and p38. We suggest that accelerated endosomal degradation of the peptidoglycan in cefoxitin-treated MRSA leads to an early expression of DUSP-1 and accordingly, a reduction in the IL-12/IL-23 ratio in dendritic cells. This may influence the clearance of S. aureus.

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