• Brown McKee posted an update 6 months, 1 week ago

    Additionally, conditioned media collected after culturing WJ-MSCs can also be used for mitigation of radiation dermatitis. Clinical translation of these findings would be possible after careful evaluation of resilience, effectiveness, and molecular mechanism of action of xenogeneic WJ-MSCs in non-human primates.

    Emerging evidences support safety and effectiveness of WJ-MSCs for treatment of acute radiation syndrome and lung injury after planned or accidental exposure. Additionally, conditioned media collected after culturing WJ-MSCs can also be used for mitigation of radiation dermatitis. Clinical translation of these findings would be possible after careful evaluation of resilience, effectiveness, and molecular mechanism of action of xenogeneic WJ-MSCs in non-human primates.

    The purpose of this survey study was to investigate the impact of Covid-19 on the lives of individuals living with primary immunodeficiency disease (PID).

    An online survey was distributed through social media to individuals with a diagnosis of PID to investigate behaviors and concerns during the Covid-19 pandemic.

    Five hundred and fifty seven responses were collected, of which 495 surveys were 100% complete; partial responses were analyzed. Respondents have been extremely cautious and have minimized their potential Covid-19 exposure risk. In this study, 56.6% (

     = 289) participated in telehealth visits with the physician responsible for managing their PID during the Covid-19 pandemic. Respondents reported they would be somewhat comfortable with returning to normal activities if there was widespread herd immunity (40.9%,

     = 209), an effective vaccine (46.0%.

     = 235), or public health protections (44.0%,

     = 225). The majority of respondents were extremely concerned (57.3%,

     = 293) about additionaas fear, anxiety, or depression, in patients with a chronic medical condition during a public health crisis such as the Covid-19 pandemic.

    Extensive COVID-19 information can generate information overload and confusion. Denmark and Sweden adopted different COVID-19 management strategies.

    This study aimed to compare search strategies, perceptions and effects of COVID-19 information, in general and specifically in social media, in residents in Denmark and Sweden.

    Quantitative data from a sample of respondents (

     = 616) from Denmark and Sweden on an international web-based survey was analysed using descriptive and analytical statistics.

    The results showed similarities between the countries regarding preferred and trusted information sources, use of (social) media, and psychosocial and behavioural effects of such information. Traditional media and social media were frequently used for COVID-19 information. Especially health authorities and researchers were trusted sources, representing the dominant medico-political discourse. There were no differences in negative effect and social behaviour. Residents in Denmark experienced significantly more positive effects than residents in Sweden.

    Summarily, the study showed similarities and small differences among residents in both countries related to usage patterns, perceptions and effects of COVID-19 information from (social) media, despite diverging strategies.

    Summarily, the study showed similarities and small differences among residents in both countries related to usage patterns, perceptions and effects of COVID-19 information from (social) media, despite diverging strategies.

    Coronavirus disease 2019 (COVID-19) is a viral illness which is transmitted through droplet spread and possibily the aerosol method. Older individuals are at higher risk compared with younger adults and children due to the presence of weaker immune functions. Healthcare workers are also at higher risk due to close proximity with the infected cases. Proper precautions and hand hygiene techniques can prevent the transmission of the disease. There is a dearth of evidence on how to manage the disease; therefore, protective measures might help to reduce the spread of infection. This article aimed to evaluate the preventive measure and use of protective equipment among healthcare workers and community settings.

    Various recent literature searched in the following databases-Medline/PubMed, CINAHL, Scopus-recommendations from centre for disease control and prevention (CDC) and World Health Organization (WHO) reports on preventive measures of COVID-19 were included.

    After reviewing the previous literature, we summarized proper precautions and hygiene techniques, use of PPE and applicability of surgical and N95 (can block 95% small particles but not resistant to oil) masks to prevent the transmission of disease.

    This viewpoint can be considered as a unique example of information on infection control and protective measures. However, due to the lack of evidence, further research is required to compare the effectiveness of medical masks and N95 masks.

    This viewpoint can be considered as a unique example of information on infection control and protective measures. However, due to the lack of evidence, further research is required to compare the effectiveness of medical masks and N95 masks.Class B1 metallo-β-lactamases (MBLs) are metalloenzymes found in drug resistant bacteria. The enzyme requires zinc ions, along with conserved amino acid coordination for nucleophilic attack of the lactam ring to induce hydrolysis and inactivation of β-lactam and some carbapenem antibiotics. GRL0617 To this date there are no clinically relevant class B1 MBL inhibitors, however L-captopril has shown significant results against NDM-1, the most difficult MBL to inhibit. Herein, we report the synthesis and evaluation of novel nucleoside analogues modified with polyethylene glycolamino (PEGA) as potential inhibitors for class B1 MBLs. Molecular dynamics simulations, using internal coordinate mechanics (ICM) algorithm, were performed on subclass B1 enzyme complex models screened with twenty-one possible PEGA-nucleosides. Analogue A, 3′-deoxy-3′-(2-(2-hydroxyethoxy)ethanamino)-β-D-xylofuranosyluracil showed superior binding, with high specificity to the conserved zinc ions in the class B1 MBL active site by utilizing key β-lactam mimic points in the uridine nucleobase.

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