Schofield Clifford

CD19(+) represented the only independent factor predicting lower CIR both in the standard-dose group (HR = 0.32 , p = 0.050) and in the intermediate-dose group (HR = 0.11 , p = 0.001). When combined, KIT(+) plus CD19(-) conferred the most increased relapse risk (3-year CIR 60%; SE 0.12). Specific KIT-D816, instead of general KITmut, may be…[Read more]

Insulin release over the course of 20 hours was better modulated in the presence of increasing PF127 content. In this study, the insulin formulations (0, 20, and 25% PF127) were administered s.c. (4 U/kg) to streptozotocin (STZ)-induced diabetic rats and blood glucose levels were monitored over 24 hours. Results In vivo blood glucose depression…[Read more]

Surface PM2.5 concentrations are required for exposure assessment studies. Remotely sensed Aerosol Optical Depth (AOD) has been used to derive PM2.5 where ground data is unavailable. However, two key challenges in estimating surface PM2.5 from AOD using statistical models are (i) Satellite data gaps, and (ii) spatio-temporal variability in…[Read more]

Surface PM2.5 concentrations are required for exposure assessment studies. Remotely sensed Aerosol Optical Depth (AOD) has been used to derive PM2.5 where ground data is unavailable. However, two key challenges in estimating surface PM2.5 from AOD using statistical models are (i) Satellite data gaps, and (ii) spatio-temporal variability in…[Read more]

A 47-year-old man was referred to our hospital for epigastric pain and cough, and was given a diagnosis of left clear cell renal carcnoma with multiple pulmonary metastases based on the results of renal tumor biopsy (cT3aN0M1). He received nivolumab/ipilimumab combination therapy, but developed diarrhea (grade 3) on day71, and treatment was…[Read more]

The outbreak of COVID-19 affected the lives of all sections of society as people were asked to self-quarantine in their homes to prevent the spread of the virus. The lockdown had serious implications on mental health, resulting in psychological problems including frustration, stress, and depression. In order to explore the impacts of this pandemic…[Read more]

The diagrams also serve as tools for comparison of metabolic networks and for interpreting high-throughput datasets, including transcriptomics, metabolomics, and reaction fluxes computed by metabolic models. These data can be overlaid on the metabolic charts to produce animated zoomable displays of metabolic flux and metabolite abundance. The…[Read more]