• Kanstrup Stephansen posted an update 6 months, 3 weeks ago

    Acute alcohol intake elevated pure-tone hearing thresholds and SRT but did not affect WRS. Both otoacoustic emissions recorded with DPOAE and the temporal resolution measured with the GIN test were not influenced by alcohol intake. The hearing performance in a noisy environment in both easy (-2 dB signal-to-noise ratio ) and difficult (-8 dB SNR) conditions was decreased by alcohol.

    Acute alcohol elevated auditory perceptive thresholds and affected performance in complex and difficult auditory tasks rather than simple tasks.

    Acute alcohol elevated auditory perceptive thresholds and affected performance in complex and difficult auditory tasks rather than simple tasks.

    To investigate the relationship of central and peripheral ghrelin during an exendin-4 (Ex-4) intervention to feeding in obese type 2 diabetic rodents.

    Animal models of diet-induced obesity (DIO) and type 2 diabetes were developed using male Sprague-Dawley rats fed with a high-fat diet and induced into DIO-streptozotocin diabetic rats. Ex-4 or the glucagon-like peptide-1 (GLP-1) receptor agonist exendin fragment- (Ex-9) was intracerebroventricularly (ICV) administered. Multivariate linear regression analysis was performed to investigate potential predictors of food intake after Ex-4 administration.

    ICV administration of Ex-4 significantly inhibited feeding and decreased weight, plasma active ghrelin, hypothalamic ghrelin, and gastric ghrelin levels. The changes in hypothalamic ghrelin and plasma ghrelin could predict the amount of 8-h average food intake. Central preadministration of Ex-9 followed by treatment with Ex-4 could inhibit the decrease in feeding at 0.5, 2, and 8 h. It could also inhibit the decrease in hypothalamic ghrelin at 0.5, 2, and 8 h, as well as in plasma and gastric ghrelin at 2 and 8 h.

    In a GLP-1 receptor-dependent manner, central and peripheral ghrelin play a vital role in the inhibition of feeding by Ex-4 administration. Hypothalamic ghrelin, but not plasma ghrelin, may be involved in central Ex-4 inhibition of feeding in the very early feeding period.

    In a GLP-1 receptor-dependent manner, central and peripheral ghrelin play a vital role in the inhibition of feeding by Ex-4 administration. Hypothalamic ghrelin, but not plasma ghrelin, may be involved in central Ex-4 inhibition of feeding in the very early feeding period.Hintergrund Bis zu 40% aller Herzpatienten können den funktionellen Herz-Kreislauf-Beschwerden (FHKB) zugeordnet werden. Dieses Krankheitsbild ist häufig mit Schlafstörungen und Blutdruckauffälligkeiten vergesellschaftet. Somit war es von Interesse, diesen Zusammenhang im Rahmen einer nichtinterventionellen Studie mit Cardiodoron® – ein Arzneimittel, das Störungen der vegetativen Rhythmik entgegenwirkt – näher zu beleuchten. Patienten und Methoden 92 Ärzte dokumentierten insgesamt 501 Patienten mit FHKB und/oder Schlafstörungen, die 3 bis 6 Monate Cardiodoron® (Dilution) erhielten. Die Subgruppe der 454 Patienten mit FHKB bzw. 269 Patienten mit vollständigen Werten wurde hinsichtlich kardiologisch relevanter Parameter genauer betrachtet und steht im Mittelpunkt dieser Publikation. Ergebnisse Die ärztlicherseits bewertete Ausprägung der FHKB reduzierte sich um 68% von 1,9 auf 0,6 Punkte. Der Symptomsummenscore aus 30 Einzelsymptomen ging um 61% von 23,6 auf 9,1 Punkte zurück. Blutdruckauffälligkeiten waren mit 1,6 zu 0,7 Punkten rückläufig. Weiterhin beurteilten die Patienten ihr Befinden mittels der Beschwerden-Liste nach von Zerssen, deren Gesamtwert sich um 58% von 24,0 auf 10,2 Punkte verminderte. Schlussfolgerung Cardiodoron® ist ein gut verträgliches Arzneimittel der anthroposophischen Therapierichtung mit positivem Effekt bei Patienten mit FHKB, insbesondere bei Blutdruckauffälligkeiten.

    Cardiovascular side effects associated with energy drink consumption may be related to effects on vascular endothelial function, heart rate, blood pressure, and electrocardiogram parameters. We sought to measure them following energy drink consumption.

    Forty-four healthy non-smoking young volunteer medical students, at an average age of 24.7 years (range 23-27 years, 34 males), with an average BMI of 23.4, received electrocardiograms and had their heart rates and blood pressures taken. Subjects then underwent baseline testing of endothelial function using the technique of endothelium-dependent flow-mediated dilatation (FMD) with high-resolution ultrasound. The subjects then drank an energy drink (24 oz Monster Energy Drink®). Hemodynamic measurements were repeated 15 and 90 min later. FMD and the electrocardiogram were repeated 90 min later. The FMD was calculated as the ratio of the post-cuff release and the baseline diameter.

    Energy drink consumption resulted in a significantly attenuated peak FMD response (mean ± SD) baseline 5.1 ± 4.1% versus post-energy drink (2.8 ± 3.8%; p = 0.004). In addition, systolic and diastolic blood pressures and heart rate increased after 15 min. Diastolic blood pressure and heart rate remained increased 90 min following energy drink consumption. There were no significant changes in electrocardiogram parameters.

    Energy drink consumption was associated with an acute significant impairment in endothelial function in young healthy adults as well as with significant hemodynamic changes. As energy drinks are becoming more popular, it is important to study their effects to better determine safe consumption patterns.

    Energy drink consumption was associated with an acute significant impairment in endothelial function in young healthy adults as well as with significant hemodynamic changes. As energy drinks are becoming more popular, it is important to study their effects to better determine safe consumption patterns.

    Critically ill patients with COVID-19 may develop multiple organ dysfunction syndrome, including acute kidney injury (AKI). We report the incidence, risk factors, associations, and outcomes of AKI and renal replacement therapy (RRT) in critically ill COVID-19 patients.

    We performed a retrospective cohort study of adult patients with COVID-19 diagnosis admitted to the intensive care unit (ICU) between March 2020 and May 2020. Multivariable logistic regression analysis was applied to identify risk factors for the development of AKI and use of RRT. The primary outcome was 60-day mortality after ICU admission.

    101 (50.2%) patients developed AKI (72% on the first day of invasive mechanical ventilation ), and thirty-four (17%) required RRT. find more Risk factors for AKI included higher baseline Cr (OR 2.50 , p = 0.005), diuretic use (OR 4.14 , p = 0.019), and IMV (OR 7.60 , p = 0.020). A higher C-reactive protein level was an additional risk factor for RRT (OR 2.12 , p = 0.

All content contained on CatsWannaBeCats.Com, unless otherwise acknowledged,is the property of CatsWannaBeCats.Com and subject to copyright.

CONTACT US

We're not around right now. But you can send us an email and we'll get back to you, asap.

Sending

Log in with your credentials

or    

Forgot your details?

Create Account