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Thestrup Heide posted an update 6 months, 2 weeks ago
We review the current technology underlying surface haptics that converts passive touch surfaces to active ones (machine haptics), our perception of tactile stimuli displayed through touch surfaces (human haptics), their potential applications (human-machine interaction), and finally the challenges ahead of us in making them available through commercial systems. This review primarily covers the tactile interactions of human fingers or hands with surface-haptics displays by focusing on the three most popular actuation methods vibrotactile, electrostatic, and ultrasonic.Identifying interactions between drugs and target proteins is a critical step in the drug development process, as it helps identify new targets for drugs and accelerate drug development. The number of known drug-protein interactions (positive samples) is much lower than that of the unknown ones (negative samples), which forms a class imbalance. Most previous methods only utilised part of the negative samples to train the prediction model, so most of the information on negative samples was neglected. Therefore, a new method must be developed to predict candidate drug-related proteins and fully utilise negative samples to improve prediction performance. We present a method based on non-negative matrix factorisation and gradient boosting decision tree (GBDT), named NGDTP, to identify the candidate drug-protein interactions. find more NGDTP integrates multiple kinds of protein similarities, drugs-proteins interactions, and multiple kinds of drugs similarities at different levels, including target proteins of drugs, drug-related diseases, and side effects of drugs. We propose a network representation learning method based on matrix factorisation to learn low-dimensional vector representations of drug and protein nodes. On the basis of these low-dimensional node representations, a GBDT-based prediction model was constructed and it obtains the association scores through establishing multiple decision trees for a drug-protein pairs. NGDTP is an ensemble learning model that fully utilises all the negative samples to effectively alleviate the problem of class imbalance. NGDTP achieves superior prediction performance when it is compared with several state-of-the-art methods. The experimental results indicate that NGDTP also retrieves more actual drug-protein interactions in the top part of prediction result, which drew significant attention from the biologists. In addition, case studies on 10 drugs further confirmed the ability of the NGDTP to identify potential candidate proteins for drugs.At present, depression has become a main health burden in the world. However, there are many problems with the diagnosis of depression, such as low patient cooperation, subjective bias and low accuracy. Therefore, reliable and objective evaluation method is needed to achieve effective depression detection. Electroencephalogram (EEG) and eye movements (EMs) data have been widely used for depression detection due to their advantages of easy recording and non-invasion. This research proposes a content based ensemble method (CBEM) to promote the depression detection accuracy, both static and dynamic CBEM were discussed. In the proposed model, EEG or EMs dataset was divided into subsets by the context of the experiments, and then a majority vote strategy was used to determine the subjects’ label. The validation of the method is testified on two datasets which included free viewing eye tracking and resting-state EEG, and these two datasets have 36,34 subjects respectively. For these two datasets, CBEM achieves accuracies of 82.5% and 92.65% respectively. The results show that CBEM outperforms traditional classification methods. Our findings provide an effective solution for promoting the accuracy of depression iden-tification, and provide an effective method for identificationof depression, which in the future could be used for the auxiliary diagnosis of depres-sion.The three-dimensional structures populated by a protein molecule determine to a great extent its biological activities. The rich information encoded by protein structure on protein function continues to motivate the development of computational approaches for determining functionally-relevant structures. The majority of structures generated in silico are not relevant. Discriminating relevant/native protein structures from non-native ones is an outstanding challenge in computational structural biology. Inherently, this is a recognition problem that can be addressed under the umbrella of machine learning. In this paper, based on the premise that near-native structures are effectively anomalies, we build on the concept of anomaly detection in machine learning. We propose methods that automatically select relevant subsets, as well as methods that select a single structure to offer as prediction. Evaluations are carried out on benchmark datasets and demonstrate that the proposed methods advance the state of the art. The presented results motivate further building on and adapting concepts and techniques from machine learning to improve recognition of near-native structures in protein structure prediction.To assist drug development, many computational methods have been proposed to identify potential drug-disease treatment associations before wet experiments. Based on the assumption that similar drugs may treat similar diseases, most methods calculate the similarities of drugs and diseases by using various chemical or biological features. However, since these features may be unknown or hard to collect, such methods will not work in the face of incomplete data. Besides, due to the lack of validated negative samples in the drug-disease associations data, most methods have no choice but to simply select some unlabeled samples as negative ones, which may introduce noises and decrease the reliability of prediction. Herein, we propose a new method (TS-SVD) which only uses those known drug-protein, disease-protein and drug-disease interactions to predict the potential drug-disease associations. In a constructed drug-proteindisease heterogeneous network, assuming that drugs/diseases relating to some common proteins or diseases/drugs may be similar, we get the common neighbors count matrix of drugs/diseases, then convert it to a topological similarity matrix.
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