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McPherson Kyed posted an update 6 months, 2 weeks ago
Image quality and heart-to-extra-cardiac ratios comparing early versus later imaging with tetrofosmin were comparable if not equivalent to each other. The equivalency of the imaging quality occurs with 15 minutes (on average) earlier imaging compared to sestamibi and 30 minutes compared to standard time tetrofosmin. The subjective findings of equivalent image quality are also shown with objective measurements of heart-to-extra-cardiac ratios. In this review, the significantly shorter injection-to-acquisition times with tetrofosmin compared to sestamibi resulted in better efficiency and less waiting times for patients; in addition, significantly higher re-scan rates with sestamibi compared to tetrofosmin due to hepatic activity contributed to better throughput with tetrofosmin.RATIONALE Coping with negative affect is central to several prominent etiological models of alcohol use. These models posit that alcohol use becomes negatively reinforced due to its ability to alleviate negative affect. However, there have been mixed findings when testing this association at the event-level. OBJECTIVES The current experience sampling study sought to clarify this by testing if (1) within-person changes in the perceived difficulty of managing emotional distress is a significant predictor of alcohol consumption, over and above levels negative and positive affect and (2) whether acute changes in affective experiences give rise to increased attentional bias toward alcohol-related cues in the environment and if attentional bias mediates the association between difficulty managing emotions and alcohol consumption. Participants were 92 college students aged 18-25, who drink alcohol at least moderately. METHODS Participants completed 28 days of experiencing sampling measures on their mood, difficulty managing emotions, alcohol-related attentional biases, and drinking. RESULTS Findings showed that neither negative affect nor difficult managing emotions had significant effects on alcohol use. However, positive affect exhibited the expected associations with both attentional biases and drinking. State positive affect predicted acute increases in attentional biases and drinking, whereas trait positive affect was inversely associated with trait attentional biases and alcohol use. Alcohol-related attentional biases exhibited significant within-person variance; however, its relationship with drinking was only significant when the constructs were assessed concurrently at night and did not mediate the relationship between affect and alcohol use. CONCLUSIONS Results highlight the importance of positive affect in this population.Perceptuomotor compatibility between phonemically identical spoken and perceived syllables has been found to speed up response times (RTs) in speech production tasks. However, research on compatibility effects between perceived and produced stimuli at the subphonemic level is limited. Using a cue-distractor task, we investigated the effects of phonemic and subphonemic congruency in pairs of vowels. On each trial, a visual cue prompted individuals to produce a response vowel, and after the visual cue appeared a distractor vowel was auditorily presented while speakers were planning to produce the response vowel. The results revealed effects on RTs due to phonemic congruency (same vs. different vowels) between the response and distractor vowels, which resemble effects previously seen for consonants. Beyond phonemic congruency, we assessed how RTs are modulated as a function of the degree of subphonemic similarity between the response and distractor vowels. Higher similarity between the response and distractor in terms of phonological distance-defined by number of mismatching phonological features-resulted in faster RTs. However, the exact patterns of RTs varied across response-distractor vowel pairs. We discuss how different assumptions about phonological feature representations may account for the different patterns observed in RTs across response-distractor pairs. Our findings on the effects of perceived stimuli on produced speech at a more detailed level of representation than phonemic identity necessitate a more direct and specific formulation of the perception-production link. Additionally, these results extend previously reported perceptuomotor interactions mainly involving consonants to vowels.Many studies have shown that not only threatening but also positive stimuli capture visual attention. However, in the dot-probe task, a common paradigm to assess attention to emotional stimuli, usually no bias towards happy faces occurs. Here, we investigated whether such a bias can occur and, if so, under which conditions. In Experiment 1, we investigated whether the bias is contingent on the simultaneous presentation of distractor stimuli with the targets. Participants performed a dot-probe task with either stand-alone targets or targets that were accompanied by distractors. We found an attentional bias towards happy faces that was not moderated by target type. To rule out perceptual low-level confounds as the cause of the bias towards happy faces, Experiments 2a and 2b comprised dot-probe tasks with inverted face cues. No attentional bias towards inverted happy faces occurred. In Experiment 3, we investigated whether a bias towards happy faces is contingent on a social-processing mode. Participants performed a dot-probe task with socially meaningful (schematic faces) or socially meaningless (scrambled schematic faces) targets. Again, a bias towards happy faces, which was not moderated by target type, occurred. In Experiment 4, we investigated the attentional bias towards happy faces when another highly relevant expression was present. Participants performed a dot-probe task with both happy and angry face cues. A significant attentional bias towards emotional faces occurred that did not differ between both cue emotions. These results suggest that happy faces are sufficiently relevant for observers to capture attention in the dot-probe task.Antimicrobial resistance (AMR) is an urgent threat to global public health and development. Mitigating this threat requires substantial short-term action on key AMR priorities. While international legal agreements are the strongest mechanism for ensuring collaboration among countries, negotiating new international agreements can be a slow process. Fluvastatin mouse In the second article in this special issue, we consider whether harnessing existing international legal agreements offers an opportunity to increase collective action on AMR goals in the short-term. We highlight ten AMR priorities and several strategies for achieving these goals using existing “legal hooks” that draw on elements of international environmental, trade and health laws governing related matters that could be used as they exist or revised to include AMR. We also consider the institutional mandates of international authorities to highlight areas where additional steps could be taken on AMR without constitutional changes. Overall, we identify 37 possible mechanisms to strengthen AMR governance using the International Health Regulations, the Agreement on the Application of Sanitary and Phytosanitary Measures, the Agreement on Trade-Related Aspects of Intellectual Property Rights, the Agreement on Technical Barriers to Trade, the International Convention on the Harmonized Commodity Description and Coding System, and the Basel, Rotterdam, and Stockholm conventions.
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