Bauer McKee

Nuclear grading systems for epithelioid malignant pleural mesothelioma (MPM) have been proposed but it remains uncertain if they could be applied in a biopsy-heavy setting. Using the proposed system, we conducted an independent, external validation study using 563 consecutive cases of epithelioid MPM diagnosed at our institution between 2003 and…[Read more]

The aberrant protein-protein interaction between calmodulin and mutant huntingtin protein in Huntington’s disease patients has been found to contribute to Huntington’s disease progression. A high-throughput screen for small molecules capable of disrupting this interaction revealed a sultam series as potent small-molecule disruptors.…[Read more]

The accuracy of the 4 topographic assessments in determining the centre coordinates of the MCL with respect to SL assessment was good no differences were found in the left eyes and although in the right eyes a more temporal and superior position of MCLs was determined (paired t-test, p less then 0.05) the difference was clinically negligible (0.16…[Read more]

Carbon dioxide (CO2) is a fundamental physiological gas known to profoundly influence the behaviour and health of millions of species within the plant and animal kingdoms in particular. A recent Royal Society meeting on the topic of ‘Carbon dioxide detection in biological systems’ was extremely revealing in terms of the multitude of roles that…[Read more]

05). In comparison with CLP group, Alp group exhibited significantly decreased concentrations of liver function markers, microscopic findings, such as decreased inflammatory cell infiltration in the interstitum, notably lowered proportion of apoptotic cells, decreased level of oxidative stress, weakened activity of the TLR4/NF-κB pathway and…[Read more]

J Am Geriatr Soc 68474-477, 2020. © 2020 The American Geriatrics Society.OBJECTIVES Brain tumor-related epilepsy patients (BTRE) have a complex profile due to the simultaneous presence of two pathologies brain tumor and epilepsy. That illness and their treatments could induce physical, cognitive, emotional disturbances, and possible social…[Read more]