Dogan Browning

Peptidase inhibitors (PIs) have been broadly studied due to their wide therapeutic potential for human diseases. A potent trypsin inhibitor from Tityus obscurus scorpion venom was characterized and named ToPI1, with 33 amino acid residues and three disulfide bonds. The X-ray structure of the ToPI1trypsin complex, in association with the mass…[Read more]

This case report adds reasonable evidence in support of food allergy as a cause of JIA.Eosinophilic gastroenteritis (EG) is a rare entity. We report a 55-year-old man had no previous atopy or allergic history, who presented abdominal pain and vomiting. Abdominal computed tomography and endoscopy ultrasonography demostrated gastric wall thickening…[Read more]

The paper reports two studies investigating children’s acquisition of the wh-adjunct zenme in Mandarin. Exarafenib Unlike other Mandarin wh-words that correspond to a single meaning, zenme can be used to question either the manner or the cause of an event. Study 1 explored whether children understand that zenme is ambiguous between a causal and a…[Read more]

The paper reports two studies investigating children’s acquisition of the wh-adjunct zenme in Mandarin. Exarafenib Unlike other Mandarin wh-words that correspond to a single meaning, zenme can be used to question either the manner or the cause of an event. Study 1 explored whether children understand that zenme is ambiguous between a causal and a…[Read more]

Upon internalization, receptors are trafficked to sorting endosomes (SE) where they undergo sorting and are then packaged into budding vesicles that undergo fission and transport within the cell. Eps15 Homology Domain Protein 1 (EHD1), the best-characterized member of the Eps15 Homology Domain Protein (EHD) family, has been implicated in…[Read more]

Upon internalization, receptors are trafficked to sorting endosomes (SE) where they undergo sorting and are then packaged into budding vesicles that undergo fission and transport within the cell. Eps15 Homology Domain Protein 1 (EHD1), the best-characterized member of the Eps15 Homology Domain Protein (EHD) family, has been implicated in…[Read more]

Approximately one-fourth of autism spectrum disorder (ASD) cases are associated with a disruptive genetic variant. Many of these ASD genotypes have been described previously, and are characterized by unique constellations of medical, psychiatric, developmental, and behavioral features. Development of precision medicine care for affected…[Read more]

Child undernutrition results in poor growth in early childhood, undermines optimal development and increases the risk of mortality. Responsive feeding has been promoted as a key intervention for improving nutritional status, however measurement of this remains difficult and has rarely considered child behaviour. We therefore developed a new…[Read more]