• Wynn Dorsey posted an update 6 months, 4 weeks ago

    Logistic regression was used to test the influence of packaging condition on the likelihood of a correct response, adjusting for key covariates. RESULTS Compared with the multiserving edible control (50.6%), participants were significantly more likely to correctly identify the serving size in the single-serving edible condition (55.3%; adjusted odds ratio = 1.22, CI , p less then .001) and the unit-dose packaging condition (54.3%; adjusted odds ratio = 1.17, CI , p less then .001). CONCLUSIONS Packaging in which each product unit contained one dose of THC enhanced consumers’ ability to identify how much of a product constitutes a standard serving or dose. Packaging products as individual doses eliminates the need for mental math and could reduce the risk of accidental overconsumption of cannabis.OBJECTIVE This study sought to examine the prospective effects of early adolescent marijuana use on late adolescent attentional and inhibitory control. Alcohol use, antisocial problems, and gender were included as statistical control variables. METHOD The community sample of 387 adolescents and a caregiver was drawn from a longitudinal study of adolescent substance use that included nine annual assessments. Adolescents were eligible if they were between ages 11 and 12 at recruitment and did not have any disabilities that would preclude them from either understanding or completing the assessment. The sample was evenly split on gender (55% female) and was predominantly non-Hispanic White (83.16%) or African American (9.07%). Attentional and inhibitory control were assessed using parent and adolescent self-reports on the Early Adolescent Temperament Questionnaire-Revised and the Adult Temperament Questionnaire. RESULTS Hypotheses were tested using structural equation modeling. High levels of early marijuana use at ages 12-14 significantly predicted low levels of adolescent attentional control at ages 18-21 (β = -.20, p less then .05), above and beyond early attentional control, early alcohol use, and antisocial problems. CONCLUSIONS Findings suggest that marijuana use may adversely affect cognitive development, especially during the sensitive period of early adolescence. Selleckchem ISRIB Results emphasize the need for further prospective work to investigate relationships between early adolescent marijuana use and the development of executive functioning.OBJECTIVE The purpose of this study was to evaluate the costs and cost-effectiveness of two treatments for 101 alcohol use disorder patients and their intimate partners–group behavioral couples’ therapy plus individual-based treatment (G-BCT), or standard behavioral couples’ therapy plus individual-based treatment (S-BCT). METHOD We estimated the per-patient cost of each intervention using a microcosting approach that allowed us to estimate costs of specific components in each intervention as well as the overall total costs. Using simple means analysis and multiple regression models, we estimated the incremental effectiveness of G-BCT relative to S-BCT. Immediately after treatment and 12 months after treatment, we computed incremental cost-effectiveness ratios (ICER) and cost-effectiveness acceptability curves for percentage days abstinent, adverse consequences of alcohol and drugs, and overall relationship functioning. RESULTS The average per-patient cost of delivering G-BCT was $674, significantly less than the cost of S-BCT ($831). However, 12 months after treatment, S-BCT participants performed better on all outcomes compared with those in G-BCT, and the calculated ICER moving from G-BCT to S-BCT ranged from $10 to $12 across these outcomes. The current findings indicated that, except at very low willingness-to-pay values, S-BCT is a cost-effective option relative to G-BCT when considering 12-month posttreatment outcomes. CONCLUSIONS As expected, G-BCT was delivered at a lower cost per patient than S-BCT; however, S-BCT performed better over time on the clinical outcomes studied. These economic findings indicate that alcohol use disorder treatment providers should seriously consider S-BCT over G-BCT when deciding what format to use in behavioral couples’ therapy.OBJECTIVE Alcohol use disorders (AUDs) are associated with high social and health care costs. We compare the direct social and health care costs of patients with AUDs, according to four service use profiles (a) AUD treatment, (b) mental health (MH) treatment, (c) AUD + MH treatment, (d) no treatment. A separate analysis of the costliest 10% is included. Furthermore, the association between the service user profile and the risk of death is examined. METHOD Direct unit service costs were retrieved from the electronic health record system and supplemented with patient grouping-based costs for primary and secondary care services, to examine the yearly mean cost per patient in the AUD cohort (N = 5,136; 71.1% male). We used data collected in the North Karelia region of Finland between 2014 and 2018. RESULTS Total costs of care for the cohort during the 5-year follow-up were 126 million Euros, and the percentage of the costliest 10% (n = 521) was 51.7% (65 million Euros). Total costs were 12,778 Euros lower if the person received AUD treatment only, compared with those not in treatment. For those receiving MH treatment only, the total costs were 1,819 Euros higher, and costs were 1,523 Euros higher for those receiving AUD + MH treatment. Receiving any treatment was associated with a diminished risk of death (AUD odds ratio = 0.56; MH OR = 0.63; AUD + MH OR = 0.41). CONCLUSIONS Receiving only AUD treatment was associated with the lowest cost of care. Our results support the early identification of AUDs and provision of treatment in specialized addiction services to lower the costs of care and improve care outcomes.OBJECTIVE The purpose of this randomized controlled study was to examine sex as a moderator of the efficacy of a brief, web-based personalized feedback intervention (eCHECKUP TO GO) on decreasing cognitive risk factors for alcohol use, increasing protective behavioral strategies, and reducing alcohol use among high school seniors. METHOD Participants (n = 311) were high school seniors randomized by class period to the eCHECKUP TO GO intervention or assessment-only control group. Participants completed online surveys at baseline and 30-day follow-up (91.0%; n = 283). RESULTS Students in the intervention group reported a significant reduction in normative perceptions of peer drinking, positive alcohol expectancies, and alcohol use relative to those in the control group. Intervention effects for perceptions of frequency of peer drunkenness and frequency of alcohol use were moderated by sex, with results favoring females. In contrast, we did not find evidence for sex as a moderator of intervention effects for normative perceptions of peer drinking frequency, sex-specific perceptions of peer heavy episodic drinking, positive alcohol expectancies, or peak drinking quantity.

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