Duffy Winkel

No marked depletion of mtDNA nor mitochondrial mass was caused by the splicing variant. However, defects that the impaired capacity of OXPHOS, reduced ATP generation, increased ROS and decreased membrane potential were observed in the mutant cells, which promoted a ubiquitin-binding mitophagy instead of apoptosis. Conclusions The novel splicing…[Read more]

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Healthcare professionals are often reluctant to deprescribe fall-risk-increasing drugs (FRIDs). Lack of knowledge and skills form a significant barrier and furthermore, there is no consensus on which medications are considered as FRIDs despite several systematic reviews. Filgotinib chemical structure To support clinicians in the…[Read more]

The accuracy of T1WI, T2WI, CET1WI, and the joint T2WI and CET1WI models ranged from 72.0 %-78.0 %, from 79.6 %-81.6 %, from 74.0 %-82.0 %, and from 76.0 %-86.0 % in the test set. In the test set, the AUC for T1WI, T2WI, CET1WI, joint T2WI, and CET1WI models ranged from 0.775 to 0.829, 0.816 to 0.826, 0.836 to 0.861, and 0.870 to 0.877,…[Read more]

This first-generation barley pan-genome makes previously hidden genetic variation accessible to genetic studies and breeding.Intensive fisheries have reduced fish biodiversity and abundance in aquatic ecosystems worldwide1-3. ‘No-take’ marine reserves have become a cornerstone of marine ecosystem-based fisheries management4-6, and their benefits…[Read more]

the model gammaherpesvirus MHV68 as a consequence of increased transcription, but that transcripts do not undergo canonical maturation into mature tRNAs. These findings underscore how tRNA expression is a highly regulated process, especially during conditions of elevated RNAPIII activity.Nitric oxide is a versatile and critical effector molecule…[Read more]

An Eudicronychinae lineage was either recovered as a sister to Melanotini or as a deep split inside Elaterinae and we herein transfer the group to Elaterinae as Eudicronychini, a new status. The mitochondrial genomes provide a sufficient signal for the placement of most lineages, but the deep bipartitions need to be compared with phylogenomic…[Read more]

Air quality prediction is a global hot issue, and PM2.5 is an important factor affecting air quality. Due to complicated causes of formation, PM2.5 prediction is a thorny and challenging task. In this paper, a novel deep learning model named temperature-based deep belief networks (TDBN) is proposed to predict the daily concentrations of PM2.5 for…[Read more]

Background Drug-eluting beads transarterial chemoembolization (DEB-TACE) has emerged as an alternative to conventional transarterial chemoembolization (cTACE) for treatment of hepatocellular carcinoma (HCC), although selection between the approaches remains controversial. Objective To compare patients with unresectable HCC treated with DEB-TACE…[Read more]

1%], and 32.4 Black ). Study 1 found that 63% to 91% of gun owners and 83% to 93% of non-gun owners supported key gun safety policies, yet both groups significantly underestimated gun owners’ support for these policies by between 12% and 31%. Studies 2 and 3 found that exposure to corrective information was associated with a small increase in…[Read more]