Hermann Swain

Early innate education of hematopoietic progenitors within the bone marrow (BM) stably primes them for either trained immunity or instead immunoregulatory functions. We herein demonstrate that in vivo or in vitro activation within the BM via Toll-like receptor-9 generates a population of plasmacytoid dendritic cell (pDC) precursors (CpG-pre-pDCs)…[Read more]

Peripheral biomarkers indicative of brain pathology are critically needed for early detection of Parkinson’s disease (PD). In this study, using NanoString and digital PCR technologies, we began by screening for alterations in genes associated with PD or atypical Parkinsonism in erythrocytes of PD patients, in which PD-related changes have been…[Read more]

Efforts to improve the prognosis of steroid-resistant gut acute graft-versus-host-disease (SR-Gut-aGVHD) have suffered from poor understanding of its pathogenesis. Here we show that the pathogenesis of SR-Gut-aGVHD is associated with reduction of IFN-γ+ Th/Tc1 cells and preferential expansion of IL-17-IL-22+ Th/Tc22 cells. The IL-22 from Th/Tc22…[Read more]

Radioembolization with yttrium-90 (Y-90) is an effective locoregional therapy for primary and metastatic liver tumors, but its use is restricted or contraindicated for patients with elevated lung shunt fraction (LSF) because of an increased risk of developing pulmonary adverse events, including but not limited to radiation pneumonitis. Elevated…[Read more]

Liver dysfunction is highlighted by several studies as a relevant complication in the context of coronavirus disease 2019 (COVID-19). We present a pediatric patient with mild phenotype but transient severe liver injury. Hepatic damage should be considered even in mild cases of the disease to ensure prompt recognition and management.

Overall,…[Read more]

Liver dysfunction is highlighted by several studies as a relevant complication in the context of coronavirus disease 2019 (COVID-19). We present a pediatric patient with mild phenotype but transient severe liver injury. Hepatic damage should be considered even in mild cases of the disease to ensure prompt recognition and management.

Overall,…[Read more]

Most high-quality studies reported that impaired awareness in early-stage AD is cross-sectionally linked with fewer depressive symptoms and anxiety symptoms (correlation ranged from -0.3 to -0.7), but with more apathy. Humancathelicidin Conclusions High-quality studies suggested that in people with early AD, impaired awareness is related to fewer…[Read more]

Recent advances in therapeutic options may prevent deterioration related to Huntington’s disease (HD), even at the pre-symptomatic stage. Be that as it may, a well-characterized patient population is essential for screening and monitoring outcome. Accordingly, the aim of this study was to describe the characteristics of a Hungarian subpopulation…[Read more]

In the article “Religiously/Spiritually Involved, but in Doubt or Disbelief-Why? Healthy?”, Mrdjenovich (in J Relig Health https//doi.org/10.1007/s10943-018-0711-2 , 2018) explored the practices of religious attendance and prayer among atheists and agnostic theists. Speed et al. (in J Relig Health https//doi.org/10.1007/s10943-020-01109-1 , 2020)…[Read more]

7% and cardiovascular mortality 4.9% vs 0.9% in patients with and without diabetes, respectively). In the multivariable analysis, diabetes remained as an independent risk factor both for overall and cardiovascular mortality. No significant interaction was found with other clinical variables.

Among patients in whom an elective invasive…[Read more]

EEG-based systems are the most accurate, with EEG being the only sensing modality capable of identifying all the stages of sleep. PPG-based systems are much simpler to use and better suited for wearable monitoring but are unable to identify all the sleep stages.The term trogocytosis refers to a rapid bidirectional and active transfer of surface…[Read more]