Haley Johansson

Type 2 Diabetes mellitus (T2DM) is a multifactorial and polygenic disorder with the molecular bases still idiopathic. Experimental analyses and tests are quite limited upon human samples due to the access, variability of patient’s conditions, and the size and complexity of the genome. Therefore, high-sugar diet exposure is commonly used for…[Read more]

then 0.001). 68Ga-ABY-025 PET yielded high test-retest reliability (relative repeatability coefficient for Patlak 30% and for the two-tissue compartment model 47%). CONCLUSION 68Ga-ABY-025 binding in HER2-positive metastases was well characterized by irreversible two-tissue compartment model wherein Ki highly correlated with SUVs at 2 and 4 h. D…[Read more]

Phosphoproteomics has drawn great attention of biologist since phosphorylation is proven to play an important role in regulation of proteins. Mass spectrometry technology has helped with the development of phosphoproteomics due to its ability in generating large amount of detailed information after analyzing the phosphoproteome samples. However,…[Read more]

Our results highlight a pathway to valleytronics in strained graphene-based platforms.Viscosities η and diffusion coefficients D_s of linear and branched alkanes at pressure 0 less then P less then 0.7  GPa and temperature T=500-600  K are calculated from molecular dynamics simulations. Combining Stokes-Einstein, free volume, and random walk con…[Read more]

Several protein monomers were unfolded using CIU, including multiple charge states of both cations and anions, and activation energies determined. ΔH⧧ and ΔS⧧ values are found to be correlated, leading to ΔG⧧ values that lie within a narrow range (∼70-80 kJ/mol) and vary more with charge state than with protein identity. ΔG⧧ is anticorrelate…[Read more]

Due to the increasing prominence of antibiotic resistance, novel drug discovery and delivery approaches targeting bacteria are essential. In this work we evaluate a prodrug design to improve the cytotoxic profile of polycationic oligothioetheramides (oligoTEAs), which are promising antimicrobials. Herein we chemically modify the oligoTEA, PDT-4G,…[Read more]