• Aarup Vad posted an update 6 months, 1 week ago

    ances of non-union.

    When intramedullary nailing is performed to treat femoral shaft fractures, multiple fractures and severe trauma do not directly affect bone union. However, it should be noted that open fracture and greater fracture severity lead to higher chances of non-union.

    Intramedullary nailing (IMN) is currently considered the gold standard in the surgical treatment of tibial shaft fractures in adult patients. In this case-control comparative study, we aimed to compare the efficacy of minimally invasive plate osteosynthesis (MIPO) and IMN in treating tibial shaft fractures.

    The clinical and radiological outcomes, such as a modified trauma scale, operation time, fracture healing, rate of re-operation, and complications such as malunion, nonunion, shortening, and infection were assessed between IMN and MIPO for the treatment of tibial shaft fractures.

    Seventy-three skeletally mature patients who underwent IMN (group I) or MIPO (group M) for a closed extra-articular tibial shaft fracture (AO/OTA type 42) from June 2010 to May 2016 were retrospectively reviewed. The mean age was 51.16 (18~79) years, and the mean follow-up period was 22 (12~50) months. Bony union was achieved in all cases but one for each group – group I (35 cases) and group M (36 cases) (p>0.05). Mean callus formation was observed in 12 (8 – 16) weeks in both groups (p>0.05). There was no significant difference in operative time, hospital stay, bone healing, and the rate of complications among the two groups (p>0.05). There was also no postoperative difference in functional evaluation between the two methods (p>0.05).

    No discrepancy was found in radiological and clinical outcomes between IMN and MIPO for tibial shaft fractures. It can be concluded that both IMN and MIPO are equally effective treatment modalities for tibial shaft fractures.

    No discrepancy was found in radiological and clinical outcomes between IMN and MIPO for tibial shaft fractures. It can be concluded that both IMN and MIPO are equally effective treatment modalities for tibial shaft fractures.With the advent of high-resolution computed tomography (HRCT), micronodular lung disease is a routinely encountered pathology in thoracic imaging. This article will review how to differentiate the three main micronodular patterns and review the differential diagnosis for each. Differential diagnosis of micronodular lung disease may be extensive, but by identifying the pattern and using additional clues, such as distribution, additional imaging findings, and clinical history, a radiologist can make an accurate diagnosis. First, three micronodular patterns – centrilobular, peri-lymphatic, and random – can be identified by using a simple algorithm based on the location of nodules. This algorithm requires understanding of the anatomy and function of the secondary pulmonary lobule. Each micronodular pattern offers a unique differential diagnosis. Centrilobular nodules can be seen with inflammatory, infectious, or vascular aetiologies; peri-lymphatic nodules with sarcoidosis and lymphangitic carcinomatosis; and random nodules with haematogenous metastases or infections.

    To compare single-shot compressed sensing (CS) cine imaging with conventional segmented cine imaging for reliable quantification of left ventricular (LV) volume and strain assessment during cardiac magnetic resonance imaging (CMRI).

    Thirty-seven participants underwent both single-shot CS and conventional segmented cines that covered the entire LV. LV volumetric and strain values were obtained. LV volumes, global strain, the standard deviation of time to peak strain (SD-TPS) in the radial, longitudinal, and circumferential directions were compared using the Student’s t-test and intraclass correlation coefficient (ICC). Interobserver and intra-observer variabilities of the LV strain values for the two cines method were determined using ICC.

    Single-shot CS cine-derived LV volumes and myocardial mass measurements correlated strongly with segmented cines (ICC >0.798) and minor systematic end-systolic volume overestimations resulting in ejection fraction underestimations. Daporinad concentration Single-shot CS cine-derived global strain and SD-TPS were poorly to moderately correlated with segmented cines (ICC from 0.045-0.706). All global strain values derived from single-shot CS cines were underestimated compared with segmented cine-derived values; however, no significant differences in radial and longitudinal SD-TPS between the two cines were found. Among the patient-related factors, heart rate was a strong predictive factor of global longitudinal strain underestimations (p=0.039) in the CS cines. Inter- and intra-observer LV strain variabilities derived from CS and segmented cines were good to excellent.

    Single-shot CS cine CMRI is feasible for the quantitative assessment of LV function. Currently, strain values derived from the two techniques are not interchangeable.

    Single-shot CS cine CMRI is feasible for the quantitative assessment of LV function. Currently, strain values derived from the two techniques are not interchangeable.

    To explore the influence of desmopressin on gonadotropin-induced spermatogenesis in patients with pituitary stalk interruption syndrome (PSIS).

    A single-center retrospective cohort study was conducted. All patients with PSIS had both gonadotropin and growth hormone (GH) deficiency. Patients were divided into desmopressin and nondesmopressin groups. The desmopressin and nondesmopressin groups were defined by the presence or absence of central diabetes insipidus, which determined whether the patient received desmopressin or not.

    The average age of gonadotropin therapy was 24.3 and 26.1 in the desmopressin and nondesmopressin groups, respectively. The rate of successful spermatogenesis in the 2 groups was 31.58% and 77.27%, respectively. The period for first sperm appearance was 13.62 ± 5.95 and 13.48 ± 6.69 months, respectively. A multivariable Cox proportional hazards model found that the adjusted hazard ratio for desmopressin was 0.260, indicating a “possible” detrimental effect of desmopressin on spermatogenesis. Central diabetes insipidus would be expected to show a similar detrimental effect. The spermatogenesis rate decreased with increased dosage of desmopressin. In the nondesmopressin group, the rate of spermatogenesis was similar between the GH group and the non-GH subgroup. The GH group had higher sperm count and concentration than the non-GH group.

    A minority of patients with PSIS had mild diabetes insipidus and received desmopressin therapy. The spermatogenesis rate decreased with increasing desmopressin dosage. In addition, GH supplementation did not affect the spermatogenesis rate.

    A minority of patients with PSIS had mild diabetes insipidus and received desmopressin therapy. The spermatogenesis rate decreased with increasing desmopressin dosage. In addition, GH supplementation did not affect the spermatogenesis rate.

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