• Aarup Vad posted an update 6 months, 3 weeks ago

    Urethral diverticula (UD) affect 1-6% of adult women. Complex UD are rare, but can be challenging to manage. To evaluate the efficacy and safety of transurethral endoscopic extensive incision of complex UD in symptomatic women.

    We retrospectively evaluated 22 female patients with complex UD who underwent transurethral endoscopic extensive incision management in our hospital. This technique was completed by one experienced surgeon over a 7-year period between August 2012 and July 2019. The surgical technique involved placing the patient in a lithotomy position, inserting the needle electrode endoscopically, and incising the tented roof of the UD from its orifice until the entire roof had been opened widely. Outcome data included complete symptom resolution rate, imaging data, de novo stress urinary incontinence (SUI), recurrence, short-term and long-term complications. Cure was defined as decreased UD volume on postoperative magnetic resonance imaging and no post-voiding urinary retention in the diverticular cavity, with symptom resolution.

    The initial symptom-resolution rate after 37.0 (27.0, 50.0) months’ follow-up was 81.80% (18/22) and the de novo SUI rate was 13.60% (3/22). No patients required additional operations after conservative therapy. There was no symptomatic or imaging recurrence, and no short-term complications.

    Transurethral endoscopic extensive incision was an effective and safe treatment for symptomatic female complex UD. Its symptom-resolution rate and de novo SUI rate might be superior to the conventional transvaginal approach. Moreover, it was less invasive and easier to conduct, with fewer complications.

    Transurethral endoscopic extensive incision was an effective and safe treatment for symptomatic female complex UD. Its symptom-resolution rate and de novo SUI rate might be superior to the conventional transvaginal approach. Moreover, it was less invasive and easier to conduct, with fewer complications.Regionalization exerts an important guiding role for sound environmental management, regional development, and schemes toward regionalizing ecological function, involving multiple levels. This paper formulated a framework for a detailed regionalization approach using the Ashi River watershed, China, as case study. Human activities, especially agriculture non-point source pollution (ANPS) and social factors, were identified as main factors. The results indicated that (1) the export coefficient model (ECM) can be used to determine ANPS loads in the watershed as well as total nitrogen and total phosphorus loads. (2) The minimum cumulative resistance model (MCR) showed that the middle and lower reaches had high risk for ANPS occurrence. (3) Based on the identified key factors, the watershed was divided into level IV and combined with existing level III using cluster analysis. Corresponding management countermeasures were proposed. This provides a scientific basis for pollution control planning and for management measures.The estuarine delta of the Yellow River is a region of strong land-ocean-human interactions that undergoes a unique evolutionary process. The delta is formed by deposition of large quantities of sediments carried by the Yellow River, especially during the annual water and sediment regulation period; more than one-third of the total annual sediments is deposited to the estuary area. The seagrass Zostera japonica is located at the forefront of the Yellow River delta. To study the impact of the different sediment environments on the Z. japonica growth, its growth and water quality and sediment parameters were measured on the northern and southern sides of the estuary from April to October in 2019. The action of wind and tides have re-suspended and dispersed sediments over time, producing shores on the southern delta characterized by nutrient-enriched clays and shores on the northern delta characterized by coarser sands and silts with poor nutrients. During the monitoring period, the concentrations of TC, TN, and TP in the root-zone sediments at the southern site were 1.56%, 0.04%, and 0.06%, respectively, whereas they were 0.69%, 0.007%, and 0.06%, respectively, at the northern site. Sufficient nutrients supported the growth of Z. japonica at the southern site, while poor nutrition limited the continuous growth of Z. japonica at the northern site. In July, the plant height, biomass, and shoot density of Z. japonica at the southern site reached the maximum values of 23.6 cm, 0.14 g/shoot, and 3245 shoots/m2, respectively, whereas they were 16.4 cm, 0.06 g/shoot, and 2740 shoots/m2, respectively, at the northern site. The sediment grain size and their nutrients contributed to different growth patterns of Z. japonica at the southern and northern sites. Our research could provide important implication for the conservation of Z. japonica habitats in the Yellow River estuary in China.Many active molecules used in the development of new drugs are produced by ants. Present study assessed antioxidant and anti-inflammatory properties of Samsum ant venom (SAV) extract in carbon tetrachloride (CCL4)-induced spleen toxicity. Toxicity and oxidative stress were measured in four experimental groups a negative control group without any treatment, a positive control group (CCl4-treated rats; a single dose of 1 ml/kg CCL4), an experimental group of CCl4-treated rats co-treated daily with SAV (100 μl), and a group to determine safe use with rats treated only with SAV (100 μl) daily for 3 weeks. CCl4-treatment led to an elevation in toxicity and oxidative stress. CCl4 significantly elevated malondialdehyde (MDA) levels, as well as expression of inhibitor of κB (IκB) and tumor necrosis factor-α (TNF-α) proteins. On the other hand, a decrease in glutathione (GSH) and catalase (CAT) levels were detected in CCl4-treated rats. Defactinib clinical trial Co-treatment with SAV was found to reduce these inflammatory and oxidative parameters. SAV elucidated a significant recovery of MDA concentration as well as a significant restoration in GSH levels compared to CCl4-treated rats; however, SAV increased CAT levels compared to normal rats. Hence, SAV was found to restore splenomegaly induced in CCl4-treated rats. Histopathological analysis also favored the biochemical analysis showing improvement in splenic architecture in CCl4 and SAV co-treated rats. The antioxidant properties of SAV may potentially enhance anti-inflammatory actions and improve spleen structure and function in CCl4-challenged rats.

All content contained on CatsWannaBeCats.Com, unless otherwise acknowledged,is the property of CatsWannaBeCats.Com and subject to copyright.

CONTACT US

We're not around right now. But you can send us an email and we'll get back to you, asap.

Sending

Log in with your credentials

or    

Forgot your details?

Create Account