Mccullough Peterson

The innate immune response, particularly the interferon response, represents a first line of defence against viral infections. The interferon molecules produced from infected cells act through autocrine and paracrine signalling to turn host cells into an antiviral state. Although the molecular mechanisms of IFN signalling have been well…[Read more]

This case was about a 71-year-old man presented to our clinic for an anterior mediastinal mass found on routine chest computed tomography (CT). CT scan showed a lobulating contoured mass in the anterior mediastinum. A preliminary diagnosis was thymoma. The patient underwent subxiphoid uniportal video-assisted thoracoscopic surgery for the extended…[Read more]

A 56-year-old woman diagnosed with type 2 gastric cancer and multiple lymph node metastases(T3N3M1, cStage Ⅳ)was treated with chemotherapy using trastuzumab with S-1 plus cisplatin for 6 cycles. The primary lesion showed PR, and lymph node metastases disappeared after the chemotherapy. Because of adverse events, she was administered with 2 a…[Read more]

Pregnancies suspicious for triple I should be terminated. The confirmation of triple I is only possible by placental histology (histologically confirmed chorioamnionitis, HCA). Confirmation based on amniocentesis (positive Gram stain, low glucose concentration , positive culture) takes too long and is unreliable. Serial determinations of…[Read more]

e the way for an approach to S. aureus-induced damage, moving towards individualized therapeutic strategies that take into account the differences between MSSA and MRSA as well as the distinctive features of the different clones. This approach is based on a change of paradigm in antibiotic therapy involving a case-based use of molecules able to…[Read more]

Combined full-thickness PKP and RD repair has good anatomic outcomes and is an efficient way to treat complex anterior and posterior segment pathology. Although post-operative visual function is limited, almost all patients were agreeable to repeat surgery if they were presented with the choice again.

Combined full-thickness PKP and RD repair…[Read more]

The self-perceived barriers include overload of responsibilities, a lack of continuing professional development, and inadequacy of communication, support and XRO courses. The facilitators, post-qualification/course training, support in undertaking examinations, primary professional roles and a small population of the rural and remote areas were…[Read more]

Colistin is a potent antibiotic which is mainly preferred in the treatment of multidrug-resistant (MDR) gram-negative bacilli. However, due to the increased risk of acute kidney injury following its use, the clinical application is limited. This nephrotoxicity is known to be induced by oxidative stress and related inflammation. In this study on…[Read more]

Our results indicated that PPI deficits and fear extinction problems were specific to rats subjected to IR and SPS, respectively. Furthermore, IR-induced PPI deficits were not influenced by SPS, but SPS-induced fear extinction retrieval impairment could be adjusted according to previous IR experiences. Neurochemically, tissue DA levels and D1R…[Read more]

The synthesis of metal-organic frameworks (MOFs) has, to date, largely been in the form of crystalline powders. However, interest in different physical morphologies of this class of materials is growing. In this perspective, we provide an overview of the structure, properties and applications of MOF monoliths. In particular, we explore the complex…[Read more]