Bradley Kjer

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Automatic functional region annotation of liver should be very useful for preoperative planning of liver resection in the clinical domain. However, many traditional computer-aided annotation methods based on anatomical landmarks or the vascular tree often fail to extract accurate liver segments. Furthermore, these methods are difficult to…[Read more]

This improvement was likely related to enhancement of glucose uptake and utilization, which are known effects of metformin in the brain. Despite reports that metformin inhibits complex I activity, our findings did not show worsening a complex I defect nor increases in lactic acid, suggesting that metformin should be further evaluated for use in…[Read more]

TRAIL is considered a promising target for cancer therapy because it mediates activation of the extrinsic apoptosis pathway in a tumor-specific manner by binding to and trimerizing its functional receptors, DR4 or DR5. Although recombinant human TRAIL has shown high potency and specificity for killing cancer cells in preclinical studies, it has…[Read more]

0±4.3°; range 1.0-18.3°) or reconstruction (5.0±3.6°; range 1.3-14°; p=0.53). Overall knee outcomes were good; the mean Lysholm score at final follow-up was 75.5±16.8 (range 36-100). No significant differences were identified in any of the sub-groups. Conclusions We were unable to identify any differences in knee proprioceptive acuity betwee…[Read more]

65), Wingate fatigue rate (r = -0.53), vertical jump (r = -0.52), and broad jump (r = -0.61), with resisted sprint tests showing the strongest associations (off-ice 15-kg resisted sprint (r = 0.79) and off-ice 30-kg resisted sprint (r = 0.74)). In multivariate analysis, stepwise regression revealed the 15-kg resisted sprint as the sole meaningful…[Read more]

The test-retest reliability presented a good agreement for the mode of commuting to school in children, distance and time to school, and the mode of commuting to work in parents, while the questions on acceptable distance to walk or cycle to school showed a moderate to good agreement. The “Family commuting-to-school behaviour” questionnaire could…[Read more]

Ventriculoatrial (VA) shunts are life-saving in circumstances where ventriculoperitoneal shunts (VP) have failed. They are at risk for different complications, and more specific of them are cardiopulmonary complications. Currently, there are no standard recommendations concerning screening for risk factors, prophylaxis, or anticoagulation…[Read more]

For those patients with valvular heart disease, cardiomyopathy, or hypertension, it is reasonable to initiate a progestin-only method until clarification of the safety of an estrogen-containing method is determined in conjunction with the patient’s cardiologist. read more Contraceptive counseling should be patient-centered, free of coercion, and…[Read more]