Bunn Acosta

Glioblastoma multiforme (GBM) is the most malignant brain tumor. Hypoxic condition is a predominant feature of the GBM contributing to tumor growth and resistance to conventional therapies. Hence, the identification of drugs able to impair GBM malignancy and aggressiveness is considered of great clinical relevance. Previously, we demonstrated that…[Read more]

We therefore suggest that two of the pyrite groups have experienced late fluid circulations that have led to partial recrystallization and dilution of S isotope mass-independent signature but not modification of the Fe isotope record. Considering the mineralogy and geochemistry of the pyrites and associated organic material, we conclude that this…[Read more]

In all the SMs, the path between “Caregiver social status” and “Caregiver knowledge” was significant. In the “C/C Functional dentitions” SM, the significant path linked “CG self-efficacy” and “Child functional dentition.” In the “C/C Dental treatment needs” SM, the significant path linked “CG self-efficacy” and “CG functional dentition.”…[Read more]

Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits1, but it remains challenging to distinguish variants that affect regulatory function2. Genomic DNase I footprinting enables the…[Read more]

ts in common wheat with potential applications for the genetic improvement of crops.Intracerebral hemorrhage (ICH) can be a devastating complication of coronavirus disease (COVID-19). We aimed to assess risk factors associated with ICH in this population. We performed a retrospective cohort study of adult patients admitted to NYU Langone Health…[Read more]

Ecstasy (MDMA) is used by approximately 370,000 Dutch people yearly, mainly young adults with a good education.<br/> AIM To describe ecstasy-related negative health effects, health risks, use profiles and crime based on data from scientific literature and other publicly available sources.<br/> RESULTS Ecstasy appears to cause little health damage…[Read more]