Hovmand Knowles

We report the case of a patient who presented for back pain with paresthesia, and the CT showed vertebral lysis of aneurysmal origin. The aneurysm of the thoracic aorta compresses the anterior surface of the dorsal vertebrae and by mechanical effect is responsible for the destruction of the opposite bone. The knowledge of this cause is very…[Read more]

We conclude by considering the potential clinical applications, including the definition of novel drug targets and the opportunity for personalization of care in this exciting new era of precision medicine.Background The existence of metabolic adaptation, at the level of resting metabolic rate (RMR), remains highly controversial, likely due to…[Read more]

Such coding geometry facilitates the decoding generalizability of temporal and nontemporal information across each other. The network structure exhibits multiple feedforward sequences that mutually excite or inhibit depending on whether their preferences of nontemporal information are similar or not. We identified four factors that facilitate…[Read more]

Background Sepsis is a fatal disease referring to the presence of a known or strongly suspected infection coupled with systemic and uncontrolled immune activation causing multiple organ failure. However, current knowledge of the role of lncRNAs in sepsis is still extremely limited. Methods We performed an in silico investigation of the gene…[Read more]

In 2006, Senegal adopted artemisinin-based combination therapy (ACT) as first-line treatment in the management of uncomplicated malaria. This study aimed to update the status of antimalarial efficacy more than ten years after their first introduction. This was a randomized, three-arm, open-label study to evaluate the efficacy and safety of…[Read more]