Smart Childers

Epithelial organoids, such as those derived from stem cells of the intestine, have great potential for modelling tissue and disease biology1-4. However, the approaches that are used at present to derive these organoids in three-dimensional matrices5,6 result in stochastically developing tissues with a closed, cystic architecture that restricts…[Read more]

Highly active anti-retroviral therapy (HAART) prolongs the life span of people living with HIV (PLWHIV) and intensely reduces HIV-related morbidity and mortality. Globally, HIV-associated non-communicable diseases are becoming major public concerns, and chronic comorbidities have appeared as a substantial reason for morbidity and mortality in HIV…[Read more]

Finally, we consider potential therapeutic avenues that target TRM cells to augment the antitumor immune response.Dendritic cells (DCs) are professional antigen-presenting cells (APCs) of the immune system. They capture foreign antigens and can present them to lymphocytes, that is, T cells and B cells, to activate them. DCs are the most potent of…[Read more]

Motion artifact contamination may adversely affect the interpretation of biological signals. The development of algorithms to detect, identify, quantify, and mitigate motion artifact is typically performed using a ground truth signal contaminated with previously recorded motion artifact, or simulated motion artifact. The diversity of available…[Read more]