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Clarke Deal posted an update 6 months, 1 week ago
These results suggest that children with ASD who have more severe ADHD symptoms are at higher risk for impairments in tasks assessing attention, immediate memory, and response inhibition-similar to ADHD-related impairments seen in the general pediatric population. As such, clinicians should assess various aspects of cognition in pediatric patients with ASD in order to facilitate optimal interventional and educational planning.
These results suggest that children with ASD who have more severe ADHD symptoms are at higher risk for impairments in tasks assessing attention, immediate memory, and response inhibition-similar to ADHD-related impairments seen in the general pediatric population. As such, clinicians should assess various aspects of cognition in pediatric patients with ASD in order to facilitate optimal interventional and educational planning.
To date, only a few studies with randomized controlled trials have been published on the effectiveness of phonics-based reading interventions to teach decoding and spelling skills to students with intellectual disability.
This study evaluated the effects of a phonics-based reading intervention program on the progress of French-speaking elementary students with intellectual disability.
A total of 48 non decoding elementary students with intellectual disability were randomly assigned to either a treatment group or a control group. Most of the participants (75 %) had nonverbal IQs below 55. The reading intervention program was implemented for seven months by the students’ teachers and mainly in a small-group format (two to four students).
Students from the treatment group made significantly more progress in word and nonword reading measured by a researcher-designed test with a medium effect size. An almost significant difference was also found on spelling (p = .058) and on word and nonword reading measured with a standardized test (p = .060) with medium effect sizes.
These findings suggest that students with ID benefit from phonics-based programs integrating research-based approaches and techniques.
These findings suggest that students with ID benefit from phonics-based programs integrating research-based approaches and techniques.
Naturalistic Developmental Behavioral Interventions (NDBI) have been evaluated as the most promising interventions for children with autism spectrum disorder. In recent years, a growing body of literature suggests that technological advancements such as Virtual Reality (VR) are promising intervention tools. However, to the best of our knowledge no studies have combined evidence-based practice with such tools.
This article aims to review the current literature combining NDBI and VR, and provide suggestions on merging NDBI-approaches with VR.
This article is divided into two parts, where we first conduct a review mapping the research applying NDBI-approaches in VR. In the second part we argue how to apply the common features of NDBI into VR-technology.
Our findings show that no VR-studies explicitly rely on NDBI-approaches, but some utilize elements in their interventions that are considered to be common features to NDBI.
As the results show, to date, no VR-based studies have utilized NDBI in their incontribute in making interventions more accessible in central as well as remote locations, while reducing unwanted variation between service sites. VNDBI will advance the possibilities of individually tailoring and widen the area of interventions. In addition, VNDBI can provide the field with new knowledge on effective components enhancing the accuracy in the intervention packages and thus move forward the research field and clinical practice.Herein, hazardous solid particulate waste collagenic fibers (SWCFs) of leather industries were incorporated into apple pomace pectin (APPN)-grafted-pentapolymer, i.e., APPN-g-, i.e., APPN-g-PENP1/ PENP2, prepared via one-pot facile polymerization of APPN and synthetic monomers, i.e., SMBD, NHMPE, and NPYPE, in aqueous medium, to fabricate an optimum multifunctional hybrid biocomposite adsorbent/ HCOM3. In PENP1, PENP2, and HCOM3, fourth/ CM1 and fifth/ CM2 multifunctional comonomers were anchored in situ. The structures of PENP1, PENP2, HCOM3, CM1, CM2, and metal-ion adsorbed HCOM3; APPN-grafting; SWCF incorporation; and surface properties were analyzed through NMR, XPS, FTIR, XRD, and SEM. The elevated adsorption efficiencies (AEs), reusability, thermostability, swelling, network durability, and crosslink density of HCOM3 were attributed to variable functionalities of SWCF/ APPN, explored by DLS and TGA, swelling, network, and thermodynamic parameters. Compared to SWCF, APPN, PENP1, and PENP2, the elevated AEs and reusability compelled HCOM3 as more suitable for scalable waste management. The maximum AEs, i.e., 171.79, 180.47, and 177.27 mg g-1, for Ti(IV), As(V), and V(V) at pHop = 7.0, 3.0, and 5.0, respectively, within 5-100 mg L-1 and at 298 K for 25 mg HCOM3 deteriorated during ternary adsorption by the antagonistic effects.The miR-15a/16-1 cluster is abnormally expressed in cervical cancer (CC) tissues and plays a vital role in cervical carcinogenesis. We aimed to evaluate the miR-15a/16-1 expression in healthy and cancerous cervical tissues, identify the associated networks, and to test its prognostic significance. miR-15a/16-1-MC expressions were analyzed in TCGA-CESC datasets by UALCAN, GEPIA2, and Datasetviewer. miR-15a/16-1 validated targets were extracted from mirTarBase and in silico functional analysis of the target genes were performed using WebGestalt. The interaction networks were constructed by the miRNet, STRING, and NetworkAnalyst tools. The prognostic significance and metastatic potential of the target genes were predicted using UALCAN and HCMDB. The FDA approved drugs to target miR-15a/16-1 and target gene network in CC were performed using DGIdb, STITCH and PanDrugs. ABT-199 TCGA-CESC and GEO data analysis suggested significant overexpression of miR-15a/16-1 in CC samples. The Kaplan-Meier survival analysis showed that miR-15a and its four target genes (BCL2, CCNE1, NUP50, and RBPJ) influence the overall survival of CC patients.
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